生薬を汚染する有害糸状菌について(第1報)市販生薬類における糸状菌分布と有害糸状菌におけるマイコトキシン生産性
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概要
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A survey of the toxigenic fungi contaminating crude drugs was carried out. Among 125 samples (93 kinds) of crude drugs commercially available in the Tokyo area and some prepared in our laboratory, 14 were found not to be contaminated. In 38 samples, 1-10 isolates of fungi were found to be growing, whereas in only 17 samples, over 50 isolates of fungi were found. On the productivity of mycotoxins, aflatoxin B_1 from Aspergillus flavus group (4/15), sterigmatocystin from A. versicolor and Emericella nidulans (4/7) and fumitremorgin from Aspergillus fumigatus (7/8) were detected. An aflatoxin-producing fungus was isolated from the bark of Akamegashiwa (Mallotus japonicus) collected in Gunma prefecture, Kanto area. Sterigmatocystin productivity in Emericella nidulans var. dentata and E. nidulans var. lata was first demonstrated. It was concluded that the crude drugs examined in this experiment were not seriously contaminated with fungus. It was especially interesting that some drugs originated in the Zingiberaceae plants, i.e. Fructus Alpiniae, Amomi, Byakuzuku, Cardamomi or Soka, were found to be only slightly contaminated.
- 公益社団法人日本薬学会の論文
- 1980-01-25
著者
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山崎 幹夫
Faculty Of Pharmaceutical Sciences Chiba University
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糸川 秀治
東京薬科大学 薬学部
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堀江 義一
(Present address)Central Museum of Chiba Prefecture
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堀江 義一
千葉大学生物活性研究所
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糸川 秀治
東京薬科大学
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