向神経性天然薬物の探索におけるマウス拘束水浸ストレス潰瘍法の応用

概要

論文の詳細を見る
Protective effect of 66 crude drugs on stress-induced ulcer in mice was examined. Of the drugs tested, Onji, Chimo, Tarakonpi, Bukuryo, Hange, Bushi, Kikyokon, Kohon, Karokon, Rensenso, Hamajisha, Sanzukon and Kujin, were found to have significant protective effect, some having effect comparable to that of certain tranquilizers. Onji, Chimo and Tarakonpi were effective when administered intraperitoneally (i.p.) and per os (p.o.). The effect of Sanzukon (and matrine) was more prominent when given p.o. than when given i.p., while Hamajisha, Rensenso, Kohon and Kikyokon were more effective when administered i.p. Acetazolamide inhibited carbonic anhydrase, while matrine did not inhibit the activity thereof matrine probably protects stress-induced ulcer by depressing central nerve system.
日本生薬学会の論文
1981-06-20