モノアミン酸化酵素阻害活性を有するトロポロン関連化合物について
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概要
- 論文の詳細を見る
The inhibitory potency towards monoamine oxidase (MAO : EC 1.4.3.4) was assayed for 33 species of tropolone related compounds. The tropolne skeleton itself had hardly participated in MAO inhibitory action, while the functional groups had affected the potency of the compounds. Azulene, a hydrocarbon with unsubstituted 5- and 7-carbon rings, inhibited MAO in the mouse liver competitively, and its IC_<50> was 59.0μM. The inhibition constants (K_1) of azulene for MAO in the mouse liver was 12.5 μM.
- 社団法人日本薬学会の論文
- 1988-08-25
著者
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佐藤 裕美子
Faculty Of Pharmaceutical Sciences Chiba University
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山崎 幹夫
千葉大学薬学部
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山崎 幹夫
Faculty Of Pharmaceutical Sciences Chiba University
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山崎 幹夫
千葉大学薬学部医薬品素材学講座
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山崎 幹夫
千葉大学
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佐藤 裕美子
千葉大学薬学部
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伊藤 椒
東北大学理学部
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