Medicinal Flowers. XXIII. New Taraxastane-Type Triterpene, Punicanolic Acid, with Tumor Necrosis Factor-α Inhibitory Activity from the Flowers of Punica granatum
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概要
- 論文の詳細を見る
The methanolic extract from the flowers of Punica granatum L. (Punicaceae) was found to show inhibitory effect on tumor necrosis factor-α (TNF-α, 1ng/ml)-induced cytotoxicity in L929 cells. By bioassay-guided separation, a new taraxastane-type triterpene, punicanolic acid (1), was isolated from the active fraction (ethyl acetate-soluble fraction) together with four triterpenes (2-5), two galloyl glucoses (6,7), two flavones (8,9), and β-sitosterol. Among the constituents, 1, oleanolic acid (2), maslinic acid (4), 1,2,6-tri-O-galloyl β-D-glucopyranoside (6),1,2-di-O-galloyl-4,6-O-(S)-hexahydroxydiphenoyl β-D-glucopyranoside (7), and luteolin (8) significantly inhibited TNF-α-induced cytotoxicity in L929 cells at 30μM.
- 社団法人日本薬学会の論文
- 2008-11-01
著者
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森川 敏生
Pharmaceutical Res. And Technol. Inst. Kinki Univ.
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吉川 雅之
Kyoto Pharmaceutical Univ.
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Morikawa Toshio
Pharmaceutical Research and Technology Institute, Kinki University
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Ninomiya Kiyofumi
Pharmaceutical Research and Technology Institute, Kinki University
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Imura Katsuya
Pharmaceutical Research and Technology Institute, Kinki University
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Yuan Dan
School of Traditional Chinese Medicine, Shenyang Pharmaceutical University
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Yoshikawa Masayuki
Pharmaceutical Research and Technology Institute, Kinki University
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Muraoka Osamu
Pharmaceutical Research and Technology Institute, Kinki University
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XIE Yuanyuan
Pharmaceutical Research and Technology Institute, Kinki University
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山崎 幹夫
千葉大学薬学部
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山崎 幹夫
千葉大学薬学部医薬品素材学講座
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Muraoka Osamu
Pharmaceutical Research And Technology Institute Kinki University
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Muraoka Osamu
近畿大学薬学総合研究所
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Dai Yue
School Of Traditional Chinese Medicine Shenyang Pharmaceutical Univ.
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Yamazaki Masatoshi
Faculty Of Pharmaceutical Sciences Teikyo University Sagamiko
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山田 美紀子
Faculty Of Pharmaceutical Sciences Chiba University
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Yamazaki M
School Of Pharmaceutical Sciences Kinki University
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Morikawa Toshio
Pharmaceutical Research And Technology Institute Kinki University
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Yuan D
Department Of Traditional Chinese Medicine Shenyang Pharmaceutical University
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Yuan Dan
Department Of Traditional Medicinal Science Hokkaido College Of Pharmacy
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Muraoka Osamu
Pharmaceutical Res. And Technol. Inst. Kinki Univ.
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Morikawa T
Research Institute Fuji Chemical Industries Ltd.
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Yuan Dan
School Of Traditional Chinese Medicine Shenyang Pharmaceutical Univ.
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Yuan D
Shenyang Pharmaceutical Univ. Shenyang Chn
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Imura Katsuya
Pharmaceutical Res. And Technol. Inst. Kinki Univ.
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Nakatani K
Pharmaceutical Res. And Technol. Inst. Kinki Univ.
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Yuan Dan
Department Of Traditional Chinese Medicines Shenyang Pharmaceutical University
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Xie Yuanyuan
Pharmaceutical Research and Technology Institute, Kinki University:School of Traditional Medicine, Shenyang Pharmaceutical University
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