Inhibitors of Nitric Oxide Production from the Rhizomes of Alpinia galanga : Structures of New 8-9' Linked Neolignans and Sesquineolignan
スポンサーリンク
概要
- 論文の詳細を見る
The 80% aqueous acetone extract from the rhizomes of Alpinia galanga showed nitric oxide (NO) production inhibitory activities in mouse peritoneal macrophages. From the aqueous acetone extract, three new 8-9' linked neolignans, galanganal, galanganols A and B, and a sesquineolignan, galanganol C, were isolated together with nine known phenylpropanoids and p-hydroxybenzaldehyde. The structures of new neolignans were determined on the basis of physicochemical and chemical evidence. In addition, the inhibitory effects of the constituents from the rhizomes of A. galanga on NO production induced by lipopolysaccharide in mouse peritoneal macrophages were examined. Among them, galanganal (IC_<50>=68μM), galanganols B (88μM) and C (33μM), 1'S-1'-acetoxychavicol acetate (2.3μM), 1'S-1'-acetoxyeugenol acetate (11μM), trans-p-hydroxycinnamaldehyde (ca.20μM), trans-p-coumaryl alcohol (72μM), and trans-p-coumaryl diacetate (19μM) were found to show inhibitory activity.
- 社団法人日本薬学会の論文
- 2005-06-01
著者
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MATSUDA Hisashi
Kyoto Pharmaceutical University
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YOSHIKAWA Masayuki
Kyoto Pharmaceutical University
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Morikawa Toshio
Kyoto Pharmaceutical University
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吉川 雅之
Kyoto Pharmaceutical Univ.
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Muraoka Osamu
Pharmaceutical Research and Technology Institute, Kinki University
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山崎 幹夫
千葉大学薬学部
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Muraoka Osamu
Pharmaceutical Research And Technology Institute Kinki University
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Muraoka Osamu
近畿大学薬学総合研究所
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Muraoka Osamu
School of Pharmacy, Kinki University
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ANDO Shin
Kyoto Pharmaceutical University
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KATAOKA Shinya
Kyoto Pharmaceutical University
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Miwa Hiroshi
三重大学 第2内科
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Muraoka Osamu
School Of Pharmaceutical Sciences Kinki University
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Yamazaki M
School Of Pharmaceutical Sciences Kinki University
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MATSUDA HISASHI
Kyoto College of Pharmacy
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