Bioactive Constituents from Chinese Natural Medicines. XIV. New Glycosides of β-Carboline-Type Alkaloid, Neolignan, and Phenylpropanoid from Stellaria dichotoma L. var. lanceolata and Their Antiallergic Activities
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概要
- 論文の詳細を見る
A new β-carboline-type alkaloidal glycoside, glucodichotomine B, four new neolignan glycosides, dichotomosides A, B, C, and D, and a new phenylpropanoid glycoside, dichotomoside E, were isolated from a Chinese natural medicine, the roots of Stellaria dichotoma L. var. lanceolata. The structures of the new glycosides were determined on the basis of chemical and physicochemical evidence. Among them, dichotomoside D inhibited the release of β-hexosaminidase (IC_<50>=64μм) as well as tumor necrosis factor-α and interleukin-4 (IC_<50>=16, 34μм) in RBL-2H3 cells. These findings suggest that dichotomoside D is more effective against the late-phase reactions in type I allergy than in the immediate phase.
- 社団法人日本薬学会の論文
- 2004-10-01
著者
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MATSUDA Hisashi
Kyoto Pharmaceutical University
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YOSHIKAWA Masayuki
Kyoto Pharmaceutical University
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Morikawa Toshio
Kyoto Pharmaceutical University
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吉川 雅之
Kyoto Pharmaceutical Univ.
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山崎 幹夫
千葉大学薬学部
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Wu Lijun
中華人民共和国
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Wu Li
School Of Traditional Chinese Materia Medica Shenyang Pharmaceutical University
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Harima S
Kyoto Pharmaceutical Univ. Kyoto Jpn
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HARIMA Shoichi
Kyoto Pharmaceutical University
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Harima Shoichi
京都薬科大学
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Harima Shoichi
Kyoto Pharmaceutical University:department Of Traditional Chinese Medicine Shenyang Pharmaceutical U
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Wu Lijun
Department Of Traditional Chinese Medicines Shenyang Pharmaceutical University
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Wu Lijun
Materials Science Division Brookhaven National Laboratory
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Shimada Hideyo
Division Of Pathophysiology School Of Pharmaceutical Sciences Kitasato University
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SUN Bohang
Kyoto Pharmaceutical University
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WU Li
Department of Traditional Chinese Medicine, Shenyang Pharmaceutical University
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Wu Li-jun
School Of Traditional Chinese Materia Medica Shenyang Pharmaceutical University
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Wang Li-bo
Kyoto Pharmaceutical University:faculty Of Natural Medicines Shenyang Pharmaceutical University
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Sun B
Kyoto Pharmaceutical University:department Of Traditional Chinese Medicine Shenyang Pharmaceutical U
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Wu Li
Department Of Cardiology Rui Jin Hospital Jiao Tong University School Of Medicine
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Wu Lijun
School Of Traditional Chinese Materia Medica Shenyang Pharmaceutical University
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MATSUDA HISASHI
Kyoto College of Pharmacy
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