Medicinal Foodstuffs. XXXIV. : Structures of New Prenylchalcones and Prenylflavanones with TNF-α and Aminopeptidase N Inhibitory Activities from Boesenbergia rotunda
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概要
- 論文の詳細を見る
The methanolic extract from the rhizomes of Boesenbergia rotunda (Zingiberaceae) was found to show inhibitory effect on tumor necrosis factor-α(TNF-α)-induced cytotoxicity in L929 cells (IC_<50>=6.1μg/ml). By bioassay-guided separation, four new prenylcalcones, (+)-krachaizin A (1a), (-)-krachaizin A (1b), (+)-krachaizin B (2a), and (-)-krachaizin B (2b), and four new prenylflavanones, rotundaflavones Ia (3a), Ib (3b), IIa (4a), and IIb (4b), were isolated together with 18 known constituents (5a-7b and 8-19). The structures of eight new compounds were elucidated on the basis of physicochemical evidence. Among them, (+)-krachaizin B (2a), (-)-krachaizin B (2b), (+)-4-hydroxypanduratin A (6a), (-)-4-hydroxypanduratin A (6b), (+)-isopanduratin A (7a), (-)-isopanduratin A (7b), alpinetin (10), cardamonin (14), and 2,6-dihydroxy-4-methoxydihydrochalcone (15) significantly inhibited TNF-α-induced cytotoxicity in L929 cells at 10 μM. In addition, 2a, 2b, (+)-panduratins A (5a), (-)-panduratin A (5b), 6a, 7b, and geranyl-2,4-dihydroxy-6-phenylbenzoate (17) were found to show strong inhibitory effects on aminopeptidase N activity.
- 社団法人日本薬学会の論文
- 2008-07-01
著者
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MATSUDA Hisashi
Kyoto Pharmaceutical University
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森川 敏生
Pharmaceutical Res. And Technol. Inst. Kinki Univ.
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吉川 雅之
Kyoto Pharmaceutical Univ.
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Morikawa Toshio
Pharmaceutical Research and Technology Institute, Kinki University
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Ninomiya Kiyofumi
Pharmaceutical Research and Technology Institute, Kinki University
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Yoshikawa Masayuki
Pharmaceutical Research and Technology Institute, Kinki University
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FUNAKOSHI Kanako
Kyoto Pharmaceutical University
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YASUDA Daisuke
Kyoto Pharmaceutical University
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MIYAGAWA Katsutoshi
Kyoto Pharmaceutical University
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山崎 幹夫
千葉大学薬学部
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松田 秀秋
近畿大学 薬学部
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山崎 幹夫
千葉大学薬学部医薬品素材学講座
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Miwa H
Second Department Of Internal Medicine Mie University School Of Medicine
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Miyashita Hiroyuki
三重大学 医学部内科学第2
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Mitani H
Second Department Of Internal Medicine Mie University School Of Medicine
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Mitani Hidetsugu
Division Of Hematology And Oncology Suzuka General Hospital
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Mitani Hidetsugu
三重大学 第2内科
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Miwa Hiroshi
三重大学 第2内科
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山田 美紀子
Faculty Of Pharmaceutical Sciences Chiba University
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Matsuda Hajime
Nihon Shokuhin Kako Co. Ltd.
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Yamazaki M
School Of Pharmaceutical Sciences Kinki University
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Matsuda Hideaki
Laboratory Of Natural Drug Resources Faculty Of Pharmacy Kinki University
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前田 初男
大阪大学大学院薬学研究科分子薬科学専攻
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前田 初男
大阪大学大学院薬学研究科
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Maeda Hatsuo
Faculty Of Pharmaceutical Sciences Osaka University
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Morikawa Toshio
Pharmaceutical Research And Technology Institute Kinki University
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Morikawa T
Research Institute Fuji Chemical Industries Ltd.
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Maeda Haruka
The Institute Of Physical And Chemical Research(riken)
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松田 久司
Kyoto Pharmaceutical Univ.
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Nakatani K
Pharmaceutical Res. And Technol. Inst. Kinki Univ.
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MATSUDA HISASHI
Kyoto College of Pharmacy
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