Activation of TRPV1 and TRPA1 by Black Pepper Components
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概要
- 論文の詳細を見る
We searched in this study for novel agonists of transient receptor potential cation channel, subfamily V, member 1 (TRPV1) and transient receptor potential cation channel, subfamily A, member 1 (TRPA1) in pepper, focusing attention on 19 compounds contained in black pepper. Almost all the compounds in HEK cells heterogeneously expressed TRPV1 or TRPA1, increased the intracellular Ca2+ concentration ([Ca2+]i) in a concentration-dependent manner. Among these, piperine, isopiperine, isochavicine, piperanine, pipernonaline, dehydropipernonaline, retrofractamide C, piperolein A, and piperolein B relatively strongly activated TRPV1. The EC50 values of these compounds for TRPV1 were 0.6–128 μM. Piperine, isopiperine, isochavicine, piperanine, piperolein A, piperolein B, and N-isobutyl-(2E,4E)-tetradeca-2,4-diamide also relatively strongly activated TRPA1, the EC50 values of these compounds for TRPA1 were 7.8–148 μM. The Ca2+ responses of these compounds for TRPV1 and TRPA1 were significantly suppressed by co-applying each antagonist. We identified in this study new transient receptor potential (TRP) agonists present in black pepper and found that piperine, isopiperine, isochavicine, piperanine, piperolein A, and piperolein B activated both TRPV1 and TRPA1.
- 社団法人 日本農芸化学会の論文
著者
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MATSUDA Hisashi
Kyoto Pharmaceutical University
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YOSHIKAWA Masayuki
Kyoto Pharmaceutical University
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NARUKAWA Masataka
Graduate School of Agriculture, Kyoto University
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Iwasaki Yusaku
Graduate School Of Nutritional And Environmental Sciences Univ. Of Shizuoka
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Okumura Yukiko
Graduate School of Nutritional and Environmental Sciences, University of Shizuoka
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Watanabe Tatsuo
Graduate School of Nutritional and Environmental Sciences, University of Shizuoka
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ISHIKAWA Aiko
School of Food and Nutritional Sciences, University of Shizuoka
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