Bioactive Constituents from Chinese Natural Medicines. XV. : Inhibitory Effect on Aldose Reductase and Structures of Saussureosides A and B from Saussurea medusa

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概要

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• The 80% aqueous acetone extract from the whole plant of Saussurea medusa MAXIM. was found to inhibit rat lens aldose reductase (IC_<50>=1.4μg/ml). From this extract, flavonoids, lignans, and quinic acid derivatives were isolated together with two new ionone glycosides, saussureosides A and B. Their absolute stereostructures were elucidated on the basis of chemical and physicochemical evidence including the application of modified Mosher's method. In addition, some isolates were found to show an inhibitory effect on aldose reductase.

• 公益社団法人日本薬学会の論文
• 2005-11-01

著者

• MATSUDA Hisashi

  Kyoto Pharmaceutical University

• YOSHIKAWA Masayuki

  Kyoto Pharmaceutical University

• Morikawa Toshio

  Kyoto Pharmaceutical University

• 吉川 雅之

  Kyoto Pharmaceutical Univ.

• XIE Haihui

  Kyoto Pharmaceutical University

• WANG Tao

  Kyoto Pharmaceutical University

• 山崎 幹夫

  千葉大学薬学部

• TANI Tadato

  Department of Pharmacognosy

• Mitani Hidetsugu

  三重大学 第2内科

• TANI Tadato

  Japan and Research Laboratories for High Quality of Life

• Yamazaki M

  School Of Pharmaceutical Sciences Kinki University

• Tani Tadato

  Department Of Kampo Pharmaceutics Institute Of Natural Medicine Toyama Medical And Pharmaceutical Un

• MATSUDA HISASHI

  Kyoto College of Pharmacy

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