Bioactive Constituents from Chinese Natural Medicines. XI Inhibitors on NO Production and Degranulation in RBL-2H3 from Rubia yunnanensis : Structures of Rubianosides II, III, and IV, Rubianol-g, and Rubianthraquinone
スポンサーリンク
概要
- 論文の詳細を見る
Three new arborinane-type triterpene glycosides, rubianosides II, III, and IV, a new arborinane-type triterpene, rubianol-g, and a new anthraquinone, rubianthraquinone, were isolated from a Chinese natural medicine, the roots of Rubia yunnanensis. The structures of the new constituents including their absolute configurations were determined on the basis of chemical and physicochemical evidence. The inhibitory effects of the isolated constituents on nitric oxide production in lipopolysaccharide-activated macrophages were examined. Among them, a cyclic peptide constituent, RA-XII and its aglycon, RA-V (deoxybouvadin), potently inhibited overproduction of nitric oxide and induction of inducible nitric oxide synthase. In addition, an anthraquinone constituent, 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone, was found to show inhibitory effects on the release of β-hexosaminidase in RBL-2H3 cells.
- 公益社団法人日本薬学会の論文
- 2003-06-01
著者
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MATSUDA Hisashi
Kyoto Pharmaceutical University
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YOSHIKAWA Masayuki
Kyoto Pharmaceutical University
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Morikawa Toshio
Kyoto Pharmaceutical University
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吉川 雅之
Kyoto Pharmaceutical Univ.
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山崎 幹夫
千葉大学薬学部
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ANDO Shin
Kyoto Pharmaceutical University
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Yamazaki M
School Of Pharmaceutical Sciences Kinki University
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TAO Jing
Kyoto Pharmaceutical University
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MATSUDA HISASHI
Kyoto College of Pharmacy
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