Antidiabetic Principles of Natural Medicines. II. Aldose Reductase and α-Glucosidase Inhibitors from Brazilian Natural Medicine, the Leaves of Myrcia multiflora DC. (Myrtacae) : Structures of Myrciacitrins I and II and Myrciaphenones A and B
スポンサーリンク
概要
- 論文の詳細を見る
The methanolic extract and ethyl acetate-soluble portion from a Brazilian natural medicine, the leaves of Myrcia multiflora DC., which has been used as a specific medicine against diabetes, were found to show inhibitory activities on aldose reductase and α-glucosidase and on the increase of serum glucose level in sucrose-loaded rats and in alloxan-induced diabetic mice. From the ethyl acetate-soluble portion, new flavanone glucosides, myrciacitrins I and II, and new acetophenone glucosides, myrciaphenones A and B, were isolated together with several known compounds such as five flavonol glycosides, myricitrin, mearnsitrin, quercitrin, desmanthin-1,and guaijaverin. The structures of new compounds were determined on the basis of physicochemical and chemical evidence. The principal components of this natural medicine including new glucosides, myrciacitrin I and myrciaphenone B, were found to show potent inhibitory activities on aldose reductase and α-glucosidase.
- 社団法人日本薬学会の論文
- 1998-01-15
著者
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MATSUDA Hisashi
Kyoto Pharmaceutical University
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YOSHIKAWA Masayuki
Kyoto Pharmaceutical University
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山崎 幹夫
千葉大学薬学部
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YAMAHARA Johji
Kyoto Pharmaceutical University
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Li Yong
Department Of Chemistry Pukyong National University
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SHIMADA Hiromi
Kyoto Pharmaceutical University
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Harima S
Kyoto Pharmaceutical Univ. Kyoto Jpn
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NISHIDA Norihisa
Kyoto Pharmaceutical University
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TOGUCHIDA Iwao
Kyoto Pharmaceutical University
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LI Yuhao
Kyoto Pharmaceutical University
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Harima Shoichi
京都薬科大学
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Harima Shoichi
Kyoto Pharmaceutical University:department Of Traditional Chinese Medicine Shenyang Pharmaceutical U
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Li Y
Nihon Univ. Funabashi Jpn
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Yamahara J
Kyoto Pharmaceutical University
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Nishida N
Kyoto Pharmaceutical University
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Lu Y.M.
Changchun Institute of Physics Academia Sinica
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Nishida N
Kyoto Pharmaceutical Univ. Kyoto Jpn
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Li Y
Cancer Institute Peking Union Medical College And Chinese Academy Of Medical Sciences
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YAMAHARA JOHJI
Kyoto College of Pharmacy
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MATSUDA HISASHI
Kyoto College of Pharmacy
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