Bioactive Constituents from Chinese Natural Medicines. XVII. Constituents with Radical Scavenging Effect and New Glucosyloxybenzyl 2-Isobutylmalates from Gymnadenia conopsea
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概要
- 論文の詳細を見る
The methanol-eluted fraction of the methanolic extract from the tubers of Gymnadenia conopsea was found to show radical scavenging activities for DPPH and super oxide anion (O_2) radicals. Three new glucosyloxybenzyl 2-isobutylmalates, gymnosides VIII, IX, and X, were isolated from this natural medicine together with 58 known constituents. The stereostructures of gymnosides were elucidated on the basis of chemical and physicochemical evidence. In addition, the phenanthrene and dihydrostilbene constituents showed radical scavenging activities and suggested the following structural requirements on radical scavenging activities; a) phenanthrenes: 1) dihydrogenation at the 9, 10-positions enhances the activities, 2) the 1 or 3-p-hydroxybenzyl group enhances the activities; b) dihydrostilbenes: 1) methylation of the 3'-position reduces the activities, 2) the 2- and/or 6-p-hydroxybenzyl groups enhance the activities.
- 公益社団法人日本薬学会の論文
- 2006-04-01
著者
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MATSUDA Hisashi
Kyoto Pharmaceutical University
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YOSHIKAWA Masayuki
Kyoto Pharmaceutical University
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Morikawa Toshio
Kyoto Pharmaceutical University
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吉川 雅之
Kyoto Pharmaceutical Univ.
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XIE Haihui
Kyoto Pharmaceutical University
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WANG Tao
Kyoto Pharmaceutical University
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山崎 幹夫
千葉大学薬学部
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Mitani Hidetsugu
三重大学 第2内科
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Yamazaki M
School Of Pharmaceutical Sciences Kinki University
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MATSUDA HISASHI
Kyoto College of Pharmacy
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