NOVEL iNDOLE S, O-BISDESMOSIDE, CALANTHOSIDE, THE PRECURSOR GLYCOSIDE OF TRYPTANTHRIN, INDIRUBIN, AND ISATIN, WITH INCREASING SKIN BLOOD FLOW PROMOTING EFFECTS, FROM TWO CALANTHE SPECIES (ORCHIDACEAE)
スポンサーリンク
概要
- 論文の詳細を見る
The methanolic extracts from Calathe discolor LINDL. and C. liukiuensis SCHLTR. were found to exhibit hair restoring and skin blood flow promoting activities. Through bioassay-guided separation using the skin blood flow increasing effect, a novel indole S, O-bisdesmoside, calanthoside, was isolated together with three new components, glucoindican, calaliukiunenoside, and calaphenanthrenol, and known compounds such as tryptathrin, indirubin, isatin, and indican. The structures of the new compounds were determined on the basis of physicochemical and chemical evidence and they showed an activating effect on skin blood flow. In addition, it was found that enzymatic hydrolysis of calanthoside with β-glucosidase furnished tryptanthrin togethwer with a small amount of indirubin and isatin, whereas indirubin and isatin were obtained from calanthoside by acid hydrolysis. Based on their contents in the fresh and dried plant, calanthoside may be a common genuine glycoside of tryptanthrin, indirubin, and isatin in the plant.
- 社団法人日本薬学会の論文
- 1998-05-15
著者
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MATSUDA Hisashi
Kyoto Pharmaceutical University
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YOSHIKAWA Masayuki
Kyoto Pharmaceutical University
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山崎 幹夫
千葉大学薬学部
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MURAKAMI Toshiyuki
Kyoto Pharmaceutical University
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角谷 真
京都薬科大学
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Matsuda Hideaki
Faculty of Pharmacy, Kinki University
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Kubo M
School Of Pharmaceutical Sciences Kinki University
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Kubo Michinori
近畿大学 薬学部
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KUBO Michinori
Faculty of Pharmaceutical Sciences, Kinki University
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KISHI Akinobu
Kyoto Pharmaceutical University
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SAKURAMA Tetsuo
Kyoto Pharmaceutical University
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NOMURA Manabu
Research & Development Department, Nomura Ltd.,
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Kishi A
Kyoto Pharmaceutical University
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Kubo Michinori
Faculty Of Pharmaceutical Sciences Kinki University
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Matsuda Hideaki
Faculty Of Pharmaceutical Sciences Kinki University
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Kubo M
Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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Nomura Manabu
Research & Development Department Nomura Ltd.
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MATSUDA HISASHI
Kyoto College of Pharmacy
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Murakami Toshiyuki
Kyoto Institute of Technology
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