Medicinal Foodstuffs. XVIII. Phytoestrogens from the Aerial Part of Petroselinum crispum MILL. (PARSLEY) and Structures of 6"-Acetylapiin and a New Monoterpene Glycoside, Petroside
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概要
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In the course of our screening for natural estrogenic compounds from Occidental medicinal herbs, the extracts of several herbs were found to show proliferative activity in MCF-7 (an estrogen-sensitive breast cancer cell line). Among these active herbs, the methanolic extract from the aerial parts of Petroselinum crispum (parsley) showed potent estrogenic activity, which was equal to that of isoflavone glycosides from soybean. Through bioassay-guided separation, we isolated several flavone glycosides and a new flavone glycoside, 6"-acetylapiin, with estrogenic activity together with a new monoterpene glucoside, petroside. The structures of 6"-acetylapiin and petroside were characterized by the chemical and physicochemical evidence. Estrogenic activities of these flavone glycosides were found to be enhanced by removal of their glycoside moieties. The EC_<50> values (concentration needed to enhance the MCF-7 proliferation 50% compared to non-estrogen treated cell) of their aglycones are as follows, apigenin (1.0 μM), diosmetin (2.9 μM), and kaempferol (0.56 μM). The estrogenic activities of these flavones are nearly equal to those of the isoflavones, daidzein (0.61 μM) and genistein (0.60 μM). The methanolic extract of parsley, apiin, and apigenin restored the uterus weight in ovariectomized mice when orally administered for consecutive 7 days.
- 社団法人日本薬学会の論文
- 2000-07-01
著者
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MATSUDA Hisashi
Kyoto Pharmaceutical University
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YOSHIKAWA Masayuki
Kyoto Pharmaceutical University
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上野 高裕
Kyoto Pharmaceutical University
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UENO Takahiro
Kyoto Pharmaceutical University
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KISHI Akinobu
Kyoto Pharmaceutical University
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Harima S
Kyoto Pharmaceutical Univ. Kyoto Jpn
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植田 知彦
京都薬科大学
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UEMURA Toshiaki
Kyoto Pharmaceutical University
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SHIMODA Hiroshi
Kyoto Pharmaceutical University
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KAWAHARA Yuzo
Research and Development Division, Morishita Jintan Co., Ltd.,
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Harima Shoichi
京都薬科大学
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Harima Shoichi
Kyoto Pharmaceutical University:department Of Traditional Chinese Medicine Shenyang Pharmaceutical U
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Kishi A
Kyoto Pharmaceutical University
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Kawahara Yuzo
Research And Development Division Morishita Jintan Co. Ltd.
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Ueda T
Faculty Of Agriculture Saga University
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Shimada Hideyo
Division Of Pathophysiology School Of Pharmaceutical Sciences Kitasato University
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Uemura Toshiaki
Department Of Information Electronics Graduate School Of Engineering Nagoya University
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Ueno Takahiro
Department Of Respiratory Diseases Institute Of Clinical Medicine University Of Tsukuba
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Yamazaki M
School Of Pharmaceutical Sciences Kinki University
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Ueno T
Kyoto Pharmaceutical University
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Ueno Takahiro
Graduate Course Of Mechanical Engineering Mie University
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MATSUDA HISASHI
Kyoto College of Pharmacy
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