Medicinal Flowers. I. Aldose Reductase Inhibitors and Three New Eudesmane-Type Sesquiterpenes, Kikkanols A, B, and C, from the Flowers of Chrysanthemum indicum L.

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概要

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• The methanolic extract from the flowers of Chrysanthemum indicum L., Chrysanthemi Indici Flos, was found to show inhibitory activity against rat lens aldose reductase. By bioassay-guided separation, the active components, such as flavone and flavone glycosides, were isolated from the extract together with three new eudesmane-type sesquiterpenes, kikkanols A, B, and C. The structures of kikkanols A, B, and C were elucidated on the basis of chemical and physicochemical evidence, which included application of the modified Mosher's method.

• 社団法人日本薬学会の論文
• 1999-03-15

著者

• MATSUDA Hisashi

  Kyoto Pharmaceutical University

• YOSHIKAWA Masayuki

  Kyoto Pharmaceutical University

• Morikawa Toshio

  Kyoto Pharmaceutical University

• 村上 孝之

  Taiho Pharmaceutical Co. Ltd.

• MURAKAMI Toshiyuki

  Kyoto Pharmaceutical University

• Harima S

  Kyoto Pharmaceutical Univ. Kyoto Jpn

• TOGUCHIDA Iwao

  Kyoto Pharmaceutical University

• HARIMA Shoichi

  Kyoto Pharmaceutical University

• Harima Shoichi

  京都薬科大学

• Harima Shoichi

  Kyoto Pharmaceutical University:department Of Traditional Chinese Medicine Shenyang Pharmaceutical U

• Shimada Hideyo

  Division Of Pathophysiology School Of Pharmaceutical Sciences Kitasato University

• MATSUDA HISASHI

  Kyoto College of Pharmacy

• Murakami Toshiyuki

  Kyoto Institute of Technology

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