Bioactive Saponins and Glycosides. VIII. Notoginseng (1) : New Dammarane-Type Triterpene Oligoglycosides, Notoginsenosides-A, -B, -C, and -D, from the Dried Root of Panax notoginseng (BURK.) F. H. CHEN

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概要

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• The glycosidic fraction from the dried roots of Panax notoginseng (BURK.) F. H. CHEN was found to show protective effect on liver injury induced by D-galactosamine and lipopolysaccharide. From the glycosidic fraction with hepatoprotective effect, nine new dammarane-type triterpene oligoglycosides, notoginsenosides-A, -B, -C, -D, -E, -G, -H, -I, and -J and an acetylenic fatty acid glycoside, notoginsenic acid β-sophoroside, were isolated together with fourteen known dammarane-type triterpene oligoglycosides. The structures of notoginsenosides-A, -B, -C, and -D were determined on the basis of chemical and physicochemical evidence, which included the chemical correlation with ginsenoside-Rb_1 using photosensitized oxygenation, as follows : notoginsenoside A; 3-O-[β-D-glucopyranosyl (1→2)-β-D-glucopyranosyl]-20-O-[β-D-glucopyranosyl (1→6)-β-D-glucopyranosyl] 3β, 12β, 20(S), 25-tetrahydroxy-dammar-23-ene, B; 3-O-[β-D-glucopyranosyl (1→2)-β-D-glucopyranosyl]-20-O-[β-D-glucopyranosyl (1→6)-β-D-glucopyranosyl] 3β, 12β, 20(S)-trihydroxy-25-en-24-one, C; 3-O-[β-D-xylopyranosyl (1→2)-β-D-glucopyranosyl (1→2)-β-D-glucopyranosyl]-20-O-[β-D-glucopyranosyl (1→6)-β-D-glucopyranosyl] 3β, 12β, 20(S)-trihydroxydammar-24ξ-hydroperoxydammar-25-ene, and D; 3-O-[β-D-glucopyranosyl (1→2)-β-D-glucopyranosyl]-20-O-[β-D-xylopyranosyl (1→6)-β-D-glucopyranosyl (1→6)-β-D-glucopyranosyl] 20(S)-protopanaxadiol, respectively.

• 社団法人日本薬学会の論文
• 1997-06-15

著者

• MATSUDA Hisashi

  Kyoto Pharmaceutical University

• YOSHIKAWA Masayuki

  Kyoto Pharmaceutical University

• 田中 修

  甲南大 理工

• 田中 修

  甲南大・理工・生物

• 山崎 幹夫

  千葉大学薬学部

• KATO Yasuyo

  Kyoto Pharmaceutical University

• MURAKAMI Toshiyuki

  Kyoto Pharmaceutical University

• MURAKAMI Nobutoshi

  Kyoto Pharmaceutical University

• 上野 高裕

  Kyoto Pharmaceutical University

• Tanaka O

  Institute Of Pharmaceutical Sciences Faculty Of Medicine Hiroshima University

• 鎌田 喜一郎

  長岡技術科学大学化学系

• YASHIRO Kenichi

  Kyoto Pharmaceutical University

• YAMAHARA Johji

  Kyoto Pharmaceutical University

• SAIJOH Reiko

  New Product Development Division, Teikoku Seiyaku Co., Ltd.,

• TANAKA Osamu

  Suzugamine Women's College

• UENO Takahiro

  Kyoto Pharmaceutical University

• HIROKAWA Nobuko

  Kyoto Pharmaceutical University

• 植田 知彦

  京都薬科大学

• UEMURA Toshiaki

  Kyoto Pharmaceutical University

• 村上 啓寿

  阪大院薬:presto

• Matsumura N

  Res. Foundation Itsuu Lab. Tokyo Jpn

• Saijoh Reiko

  New Product Development Division Teikoku Seiyaku Co. Ltd.

• Yamahara J

  Kyoto Pharmaceutical University

• Uemura Toshiaki

  Department Of Information Electronics Graduate School Of Engineering Nagoya University

• Ueno Takahiro

  Department Of Respiratory Diseases Institute Of Clinical Medicine University Of Tsukuba

• Ueno T

  Kyoto Pharmaceutical University

• Tanaka O

  Department Of Biology Faculty Of Science And Engineering Konan University

• Ueno Takahiro

  Graduate Course Of Mechanical Engineering Mie University

• Saijoh Reiichi

  Unit Of Chemistry Faculty Of Engineering And High Technology Research Center Kansai University

• Tanaka O

  Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine

• YAMAHARA JOHJI

  Kyoto College of Pharmacy

• MATSUDA HISASHI

  Kyoto College of Pharmacy

• Murakami Toshiyuki

  Kyoto Institute of Technology

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