P-30 チャ(Camellia sinensis)およびツバキ(C. japonica)花部,種子および葉部の生体機能性サポニン(ポスター発表の部)
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概要
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During the course of our characterization studies on bioactive saponins, the saponin fraction from the flowers, seeds of Camellia sinensis and C. japonica were found to show biological activities (gastroprotective, inhibitory effect on serum triglyceride (TG) elevation, and platelet aggregating effects, and so on). Therefore, we tried to isolate various bioactive saponin constituents from Camellia sinensis and C. japonica. 1. Camellia sinensis We have isolated nine new compounds [floratheasaponins A-I] from the flowers, twenty-three new compounds [theasaponins A_1-A_5, C_1, E_3-E_<13>, F_1-F_3, G_1, G_2 and H_1] from the seeds, and six new compounds [foliatheasaponins I-VI] from the leaves of C. sinensis. Floratheasaponins from the flowers were found to inhibit serum TG elevation in olive oilloaded mice. Theasaponins A_2 and E_2 showed inhibitory effects on ethanol-induced gastric mucosal lesions in rat, and their effects were stronger than that of reference compound, cetraxate hydrocholoride. 2. Camellia. Japonica We have isolated nine new compounds [camelliosides A-D, sanchasaponins A-D] from the flowers and six new compounds [camelliasaponins A_1, A_2, B_1, B_2, C_1, and C_2,] of C. japonica. Camelliosides, A and B showed gastroprotective and platelet aggregating effects. In addition, camelliasaponins B_1, B_2, C_1, and C_2 were found to exhibit inhibitory activity on ethanol absorption.
- 天然有機化合物討論会の論文
- 2006-09-15
著者
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長友 暁史
京都薬科大学
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森川 敏生
Pharmaceutical Res. And Technol. Inst. Kinki Univ.
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村上 敏之
京都薬科大学生薬学教室
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吉川 雅之
Kyoto Pharmaceutical Univ.
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村上 孝之
Taiho Pharmaceutical Co. Ltd.
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李 寧
京都薬大
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Miwa H
Second Department Of Internal Medicine Mie University School Of Medicine
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Miyashita Hiroyuki
三重大学 医学部内科学第2
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松田 久司
京都薬大
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吉川 雅之
京都薬大
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森川 敏生
京都薬大
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Mitani H
Second Department Of Internal Medicine Mie University School Of Medicine
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中田 幸子
Kyoto Pharmaceutical University
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Matsuda Hideaki
近畿大学 薬
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Miwa Hiroshi
三重大学 第2内科
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Murakami Takayuki
Taiho Pharmaceutical Co. Ltd.
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Matsuda Hajime
Nihon Shokuhin Kako Co. Ltd.
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中村 誠宏
京都薬大
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Miyazaki Tomoko
Suntory Institute For Biomedical Research Wakayamadai
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Murakami T
Department Of Microbiology Tokyo Medical And Dental University School Of Medicine
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加藤 泰世
京都薬大
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長友 暁史
京都薬大
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池 桂花
京都薬大
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大串 輝樹
京都薬大
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浅尾 恭伸
京都薬大
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松田 久司
Kyoto Pharmaceutical Univ.
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