Study on Anti-Oketsu Activity of Rhubarb II. Anti-allergic Effects of Stillbene Components from Rhei undulati Rhizoma(Dried Rhizome of Rheum undulatum Cultivated in Korea)

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概要

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• Methanol extract(RM-ext)obtained from the dried rhizome of Rheum unfulatum was screened for actovity in experimental models of type I allergy. RM-ext exhibited the inhibition on 48-h homologous passive cutaneous anaphyulaxis(PCA)in rats and and antigen-induced histamine release from rat peritoneal mast cells. Among nine stibenes isolated from RM-ext, seven inhibited the histamine release. Rhapontigenin(compound 1), piceatannol(2)and piceatannol 3´-β-_D-glycoside(6)with oral administration showed the inhibition on PCA. Compounds 1 and 2 exhibited the inhibitory effect on sheep red blood cell-induced delayed-type hyper sensitivity(SRBC-DTH)of type IV allergic model. These results indicated that the rhizome of Rheum undulatum inhibits the allergic reactions and that these inhibitory effects may be partially atributable to the stillbenes mentioned above.

• 社団法人日本薬学会の論文
• 2001-03-01

著者

• YOSHIKAWA Masayuki

  Kyoto Pharmaceutical University

• 吉川 雅之

  Kyoto Pharmaceutical Univ.

• 角谷 真

  京都薬科大学

• Matsuda Hideaki

  Faculty of Pharmacy, Kinki University

• Kubo M

  School Of Pharmaceutical Sciences Kinki University

• Kubo Michinori

  近畿大学 薬学部

• KUBO Michinori

  Faculty of Pharmaceutical Sciences, Kinki University

• TOMOHIRO Norimichi

  Medicinal Herb Garden, Faculty of Pharmaceutical Sciences, Kinki University

• TOMOHIRO Norimichi

  Faculty of Pharmaceutical Sciences, Kinki University

• HIRABA Keiichiro

  Faculty of Pharmaceutical Sciences, Kinki University

• HARIMA Shoichi

  Faculty of Pharmaceutical Sciences, Kinki University

• KO Sungkwon

  Faculty of Pharmaceutical Sciences, Kinki University

• MATSUO Keizo

  Faculty of Pharmaceutical Sciences, Kinki University

• Ko Sungkwon

  Faculty Of Pharmaceutical Sciences Kinki University

• Matsuo Keizo

  近畿大学 薬

• Harima Shoichi

  Faculty Of Pharmaceutical Sciences Kinki University

• Kubo Michinori

  Kyoto Pharmaceutical University

• Kubo Michinori

  Faculty Of Pharmaceutical Sciences Kinki University

• Yamazaki M

  School Of Pharmaceutical Sciences Kinki University

• Matsuda Hideaki

  Faculty Of Pharmaceutical Sciences Kinki University

• Tomohiro Norimichi

  Medicinal Herb Garden Faculty Of Pharmaceutical Sciences Kinki University

• Matsuo Kazuya

  Pharmaceutical Research Laboratory Hokuriku Seiyaku Co. Ltd.:department Of Pharmaceutics Kanazawa Un

• Kubo M

  Kampo And Pharmacognosy Laboratory Tsumura And Co.

• Kubo M

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• Matsuo Keizo

  Faculty Of Pharmaceutical Sciences Kinki University

• Hiraba Keiichiro

  Faculty Of Pharmaceutical Sciences Kinki University

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