Studies on Alismatis Rhizoma. II. Anti-complementary Activities of Methanol Extract and Terpene Components from Alismatis Rhizoma (Dried Rhizome of Alisma orientale)
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概要
- 論文の詳細を見る
A methanol extract (TMe-ext) from the dried rhizome of Alisma orientale was screened for anti-complemenetary activity in experimental models. In the animal models, it was found that TMe-ext inhibits zymosan-induced hind paw edema in rats and zymosan-activated rat serum (ZAS)-induced vascular permeability in mice. TMe-ext showed an inhibitory effect on complement-induced hemolysis through both the classical pathway and the alternative pathway. And TMe-ext inhibited hypotonic shock-induced hemolysis, but this effect was weak compared with the anti-complementary activities of TMe-ext. Four triterpenes (alisol A, alisol A monoacetate, alisol B and alisol B monoacetate) isolated from the rhizome also inhibited the complement-induced hemolysis through the classical pathway, but two sesquiterpenes (alismol and alismoxide) were ineffective. These results indicate that Alismatis Rhizoma shows anti-complementary activity, and its anti-complementary components are partially attributable to the terpene components mentioned above.
- 社団法人日本薬学会の論文
- 1998-12-15
著者
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YOSHIKAWA Masayuki
Kyoto Pharmaceutical University
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角谷 真
京都薬科大学
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Matsuda Hideaki
Faculty of Pharmacy, Kinki University
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Kubo M
School Of Pharmaceutical Sciences Kinki University
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Kubo Michinori
近畿大学 薬学部
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KUBO Michinori
Faculty of Pharmaceutical Sciences, Kinki University
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TOMOHIRO Norimichi
Medicinal Herb Garden, Faculty of Pharmaceutical Sciences, Kinki University
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TOMOHIRO Norimichi
Faculty of Pharmaceutical Sciences, Kinki University
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Kubo Michinori
Kyoto Pharmaceutical University
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Kubo Michinori
Faculty Of Pharmaceutical Sciences Kinki University
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Matsuda Hideaki
Faculty Of Pharmaceutical Sciences Kinki University
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Tomohiro Norimichi
Medicinal Herb Garden Faculty Of Pharmaceutical Sciences Kinki University
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Kubo M
Kampo And Pharmacognosy Laboratory Tsumura And Co.
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Kubo M
Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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