Studies on Kochiae Fructus IV. Anti-Allergic Effects of 70% Ethanol Extract and Its Component, Momordin Ic from Dried Fruits of Kochia scoparia L.
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概要
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The 70% ethanol extract (KS-ext) from Kochiae Fructus (dried fruits of Kochia scoparia L.) has been screened for activity in experimental models of type I-IV allergy. In type I allergic models, KS-ext at doses of 200 and 500 mg/kg, p.o. exhibited an inhibitory effect on 48-h homologous passive cutaneous anaphylaxis (PCA) in rats, which is related to IgE, and 1.5-h heterologous PCA in mice, which is related to IgG. In a type III allergic model, KS-ext showed an inhibitory effect on direct passive arthus reaction (DPAR) in rats, while it had no inhibitory effect on reversed cutaneous anaphylaxis (RCA) in a type II allergic model. Furthermore, in a type IV allergic model, KS-ext had an inhibitory effect on the effector phase in picryl chloride-induced contact dermatitis (PC-CD). Also, its anti-pruritogenic component, momordin Ic (oleanane saponin) exhibited inhibitory effects on 48-h homologous PCA and PC-CD.These results indicate that Kochiae Fructus not only inhibits humoral immunity but also influences cellular immunity, and should be recognized as a material for anti-allergic reactions. Also, the mode of its anti-pruritogenic activity may be mediated by anti-allergic action, and its active component may be partially attributed to momordin Ic.
- 1997-11-15
著者
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YOSHIKAWA Masayuki
Kyoto Pharmaceutical University
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角谷 真
京都薬科大学
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Matsuda Hideaki
Faculty of Pharmacy, Kinki University
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Kubo Michinori
近畿大学 薬学部
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KUBO Michinori
Faculty of Pharmaceutical Sciences, Kinki University
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IDO Yasuko
Faculty of Pharmaceutical Sciences, Kinki University
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DAI Yue
China Pharmaceutical University
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Dai Yue
School Of Traditional Chinese Medicine Shenyang Pharmaceutical Univ.
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Kubo Michinori
Faculty Of Pharmaceutical Sciences Kinki University
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Matsuda Hideaki
Faculty Of Pharmaceutical Sciences Kinki University
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Yuan D
Department Of Traditional Chinese Medicine Shenyang Pharmaceutical University
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Yuan Dan
Department Of Traditional Medicinal Science Hokkaido College Of Pharmacy
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Dai Y
School Of Traditional Chinese Medicine Shenyang Pharmaceutical Univ.
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Yuan D
Shenyang Pharmaceutical Univ. Shenyang Chn
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Kubo M
Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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Ido Yasuko
Faculty Of Pharmaceutical Sciences Kinki University
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Yuan Dan
Department Of Traditional Chinese Medicines Shenyang Pharmaceutical University
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