A Hydroxyl Group of Flavonoids Affects Oral Anti-inflammatory Activity and Inhibition of Systemic Tumor Necrosis Factor-α Production
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概要
- 論文の詳細を見る
We previously reported that oral administration of luteolin can inhibit serum tumor necrosis factor (TNF)-α production and several inflammatory and allergic models. We investigated here the effect of various flavonoids which resemble luteolin in structure. Lipopolysaccharide (LPS)-induced TNF-α production from macrophages was inhibited by treatment with flavone (luteolin, apigenin, and chrysin), flavonol (quercetin and myricetin), flavanonol (taxifolin), and anthocyanidin (cyanidin chloride) in vitro. Most of these, however, did not affect mice when administered orally. Serum TNF-α production was inhibited only by luteolin or apigenin, and only luteolin or quercetin inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear edema. These results suggest that the structure of luteolin: 3′,4′,5,7-tetrahydroxyflavone, is most suitable for the oral anti-inflammatory activity and that existence or disappearance of a hydroxy group may cause a loss of efficiency.
- 社団法人 日本農芸化学会の論文
- 2004-01-23
著者
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UEDA Hiroshi
Department of Pathology, School of Medicine Gifu University
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YAMAZAKI Masatoshi
Department of Medical Life Chemistry, Faculty of Pharmaceutical Sciences, Teikyo University
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山崎 幹夫
千葉大学薬学部
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Yamazaki M
Department Of Medical Life Chemistry Faculty Of Pharmaceutical Sciences Teikyo University
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Yamazaki M
School Of Pharmaceutical Sciences Kinki University
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YAMAZAKI Chikako
Department of Medical Life Chemistry, Faculty of Pharmaceutical Sciences, Teikyo University
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Yamazaki Masatoshi
Department Of Circulation Research Institute Of Environmental Medicine Nagoya University
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Ueda H
Natural Medicinal Chemistry Kobe Pharmaceutical University
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Ueda Hiroshi
Department Of Dermatology Fujita Health University School Of Medicine
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Yamazaki Chikako
Department Of Medical Life Chemistry Faculty Of Pharmaceutical Sciences Teikyo University
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Ueda Hiroshi
Department Of Anatomy University Of Occupational And Environmental Health School Of Medicine
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Ueda Hiroshi
Department Of Anatomy School Of Medicine University Of Occupational And Environmental Health
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Yamazaki Masatoshi
Department of Cardiovascular Research, Research Institute of Environmental Medicine, Nagoya University
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