Effects of Acute Nicotine on Catecholamine Turnover in Various Rat Brain Regions
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概要
- 論文の詳細を見る
Acute effects of in vivo nicotine application on turnover rates of noradrenaline (NA), adrenaline (AD) and dopamine (DA) in rat occipital cortex, hippocampus, striatum, hypothalamus, thalamus, midbrain, pons/medulla and cerebellum were examined by determining the amine concentrations by high performance liquid chromatography. The regional turnover rates of catecholamines were evaluated by comparing the decline in concentrations produced by blockade of synthesis. Intraperitoneally injected fusaric acid (80 mg/kg), an inhibitor of dopamine-β-hydroxylase, significantly decreased NA concentration in all eight regions examined, and AD concentration in the hypothalamus and pons/medulla. α-Methyl-p-tyrosine methylester (α-MPT, 400 mg/kg), an inhibitor of the tyrosine hydroxylase, induced significant and uneven decreases in regional DA concentrations 1 h after the i.p. injection. α-MPT also significantly decreased NA concentration in all the regions except the striatum. Subcutaneously injected nicotine 0.4-1 mg/kg significantly enhanced the fusaric acid-induced decline in NA concentrations in the hippocampus and cerebellum. AD decline in the midbrain by fusaric acid was significantly accelerated by nicotine (0.4 mg/kg), but was not affected by a larger dose (1 mg/kg). In the hippocampus, nicotine (1mg/kg) significantly enhanced the α-MPT-induced decrease in NA concentration, while it reduced the decrease in DA concentration. These findings suggest that nicotine can affect the turnover of brain catecholamine in a regionally specific manner.
- 公益社団法人日本薬学会の論文
- 1989-09-01
著者
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UEDA Hiroshi
Department of Pathology, School of Medicine Gifu University
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Akema Noriko
Department Of Pharmacology Yokohama City University School Of Medicine:(present Address)the Second D
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AMANO Hiroo
Department of Dermatology, Gunma University Graduate School of Medicine
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Amano Hiro
Department Of Pharmacology Yokohama City University School Of Medicine:(present Address)division Of
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Amano Hiroo
Department Of Dermatology Gunma University Graduate School Of Medicine
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KUBO Takao
Department of Pharmacology, Showa College of Pharmaceutical Sciences
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Kubo T
Department Of Pharmacology Yokohama City University School Of Medicine
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Kubo Takao
Department Of Pharmacology Showa College Of Pharmaceutical Sciences
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GOSHIMA Yoshio
Department of Pharmacology, Yokohama City University School of Medicine
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MISU Yoshimi
Department of Pharmacology, Yokohama City University School of Medicine
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Kambe T
Department Of Pharmacology Showa Pharmaceutical University
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Misu Yoshimi
Department Of Pharmacology Yokohama City University School Of Medicine
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Goshima Yoshio
Department Of Pharmacology Yokohama City University School Of Medicine
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Ueda Hiroshi
Department Of Dermatology Fujita Health University School Of Medicine
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Goshima Yoshio
Department Of Molecular Pharmacology And Neurobiology Yokohama City University Graduate School Of Me
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Goshima Yoshio
Department Of Molecular Neuropharmacology Yokohama City University Graduate School Of Medicine
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Ueda Hiroshi
Department Of Pharmacology Yokohama City University School Of Medicine:(present Address)dept. Of Pha
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Ueda Hiroshi
Department Of Anatomy University Of Occupational And Environmental Health School Of Medicine
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Ueda Hiroshi
Department Of Anatomy School Of Medicine University Of Occupational And Environmental Health
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MISU Yoshimi
Department of Pharmacologv, faculty of Pharmaceutical Scieuces, Kyoto University
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