Luteolin as an Anti-inflammatory and Anti-allergic Constituent of Perilla frutescens
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概要
- 論文の詳細を見る
Oral administration of the perilla leaf extract (PLE) to mice inhibits inflammation, allergic response, and tumor necrosis factor-α production. We also found that PLE suppressed the tumor necrosis factor-α (TNF-α) production in vitro. Using the inhibitory activity of TNF-α production in vitro as the index for isolation, we searched the active constituents from PLE and isolated luteolin, rosmarinic acid and caffeic acid as active components. Among the isolated compounds, only luteolin showed in vivo activity: inhibition of serum tumor necrosis factor-α production, inhibition of arachidonic acid-induced ear edema, inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced ear edema and inhibition of oxazolone-induced allergic edema. These results suggest that luteolin is a genuinely active constituent which is accountable for the oral effects of perilla.
- 公益社団法人日本薬学会の論文
- 2002-09-01
著者
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UEDA Hiroshi
Department of Pathology, School of Medicine Gifu University
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YAMAZAKI Masatoshi
Department of Medical Life Chemistry, Faculty of Pharmaceutical Sciences, Teikyo University
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山崎 幹夫
千葉大学薬学部
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Yamazaki M
Department Of Medical Life Chemistry Faculty Of Pharmaceutical Sciences Teikyo University
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Yamazaki M
School Of Pharmaceutical Sciences Kinki University
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YAMAZAKI Chikako
Department of Medical Life Chemistry, Faculty of Pharmaceutical Sciences, Teikyo University
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Yamazaki Masatoshi
Department Of Circulation Research Institute Of Environmental Medicine Nagoya University
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Ueda H
Natural Medicinal Chemistry Kobe Pharmaceutical University
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Ueda Hiroshi
Department Of Dermatology Fujita Health University School Of Medicine
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Yamazaki Chikako
Department Of Medical Life Chemistry Faculty Of Pharmaceutical Sciences Teikyo University
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Ueda Hiroshi
Department Of Anatomy University Of Occupational And Environmental Health School Of Medicine
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Ueda Hiroshi
Department Of Anatomy School Of Medicine University Of Occupational And Environmental Health
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Yamazaki Masatoshi
Department of Cardiovascular Research, Research Institute of Environmental Medicine, Nagoya University
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