Anti-tumor Effects of Orally Administered Soft-Shelled Turtle Powder in Mice
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概要
- 論文の詳細を見る
The effects of oral administration of cryomilled powder of the soft-shelled turtle (SST powder) on solid and ascites tumor-bearing C3H/He mice were studied. The SST powder was administered orally at a dose of 100 or 500mg/kg/d for two or four weeks, and then MH134 hepatoma cells were inoculated; oral administration was continued after inoculation. Treatment with the SST powder attenuated the increase in diameter and weight of the tumor and prolonged the survival of mice with solid tumors. However, the same treatment did not show any significant effect in mice with ascites tumor, indicating that the SST powder has no direct killing action on tumor cells. These results suggest that oral administration of the SST powder decreases the growth of solid tumors possibly by activating the host immune system.
- 公益社団法人日本薬学会の論文
- 1996-03-15
著者
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YAMAZAKI Masatoshi
Department of Medical Life Chemistry, Faculty of Pharmaceutical Sciences, Teikyo University
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松本 直章
東京大学大学院農学生命科学研究科獣医臨床病理学教室
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SAITO HIROSHI
Department of Neurology, Tohoku University School of Medicine
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Feng H
Univ. Tokyo Tokyo Jpn
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Matsuki Norio
Lab. Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences The Univ. Of Tokyo Jpn
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Matsuki N
Univ. Tokyo Tokyo Jpn
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Feng Hong
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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斉藤 博満
協和発酵・東京研
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Matsuki Norio
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences
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Matsuki Norio
Graduate School Of Pharmaceutical Sciences The University Of Tokyo
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Yamazaki Masatoshi
Department Of Circulation Research Institute Of Environmental Medicine Nagoya University
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Yamazaki Masatoshi
Department Of Medicinal Chemistry Teikyo University
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Saito H
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Saito Hideyuki
Department Of Pharmacology College Of Pharmacy Nihon University
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Saito H
Department Of Pharmacology College Of Pharmacy Nihon University
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Saito Hiroshi
Department Of Cardiovascular Medicine Osaka University Graduate School Of Medicine
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Matsuki Norio
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences The University Of Tok
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Yamazaki Masatoshi
Department of Cardiovascular Research, Research Institute of Environmental Medicine, Nagoya University
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Saito Hiroshi
Department of Applied Chemistry, Graduate School of Engineering, Tohoku University
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