Ca^<2+>-Independent Phospholipase A_2 Inhibitor Impairs Spatial Memory of Mice
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概要
- 論文の詳細を見る
Pharmacological blockade of Ca2+−independent phospholipase A2(PLA2)is reported to disintegrate hippocampal synaptic plasticity, which is thought to be the cellular mechanism underlying learning and memory.Therefore, we investigated the effect of the Ca2+−independent PLA2 inhibitor bromoenol lactone(BEL)on spontaneous alteration behaviors of mice.When 3 nmol BEL was intracerebroventricularly injected 30 min prior to the test, the mice showed a poor alternation ratio, compared with control animals.The data suggest that Ca2+−independent PLA2 activity is required for spatial memory.
- 社団法人 日本薬理学会の論文
- 2000-07-01
著者
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松本 直章
東京大学大学院農学生命科学研究科獣医臨床病理学教室
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IKEGAYA Yuji
Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Science, The University of To
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Ikegaya Yuji
Univ. Tokyo Tokyo
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Ikegaya Yuji
Lab. Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences The Univ. Of Tokyo Jpn
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Ikegaya Yuji
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Science The University Of Toky
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Matsuki Norio
Lab. Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences The Univ. Of Tokyo Jpn
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Matsuki N
Univ. Tokyo Tokyo Jpn
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Matsuki Norio
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences The Universe Of Tokyo
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Matsuki Norio
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences The University Of Tok
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FUJITA Shinichi
Laboratory of Urban Landscape Design, College of Agriculture
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Matsuki Norio
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences
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Matsuki Norio
Graduate School Of Pharmaceutical Sciences The University Of Tokyo
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Fujita Shinichi
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences The University Of Tok
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NISHIYAMA Nobuyoshi
Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of T
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Nishiyama N
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences The Universe Of Tokyo
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Nishiyama Nobuyoshi
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences The University Of Tok
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Matsuki Norio
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences The University Of Tok
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Matsuki Norio
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences The University Of Tok
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Matsuki Norio
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences The University Of Tok
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Matsuki Norio
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences The University Of Tok
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Matsuki Norio
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences The University Of Tok
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池田 友子
Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo
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