Nitric Oxide but Not Carbon Monoxide Is Involved in Spatial Learning of Mice

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概要

• 論文の詳細を見る

• The aim of the present study was to elucidate the role of carbon monoxide (CO) in learning and to compare it with that of nitric oxide (NO). Effects of an inhibitor of heme oxygenase which produces CO, Zn-protoporphyrin IX, on passive avoidance learning and spatial learning in mice were examined using step through, step down and water maze tests. Zn-protoporphyrin IX (10, 20 nmol, i.c.v.) affected neither type of learning. In contrast, <I>N</I>-ω-nitro-L-arginine (40 nmol, i.c.v.), an inhibitor of NO synthase, impaired spatial learning, but not passive avoidance learning. These results suggest that NO but not CO is involved in spatial learning.

• 社団法人 日本薬理学会の論文

著者

• Matsuki Norio

  Lab. Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences The Univ. Of Tokyo Jpn

• Matsuki N

  Univ. Tokyo Tokyo Jpn

• Matsuki Norio

  Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences

• Matsuki Norio

  Graduate School Of Pharmaceutical Sciences The University Of Tokyo

• Matsuki Norio

  Department Of Chemical Pharmacology Faculty Of Pharmaceutical Science The University Of Tokyo

• Saito Hiroshi

  Department Of Cardiovascular Medicine Osaka University Graduate School Of Medicine

• Matsuki Norio

  Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences The University Of Tok

• TOYODA Miwa

  Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo

• Toyoda Miwa

  Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo

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