Emesis induced by cancer chemotherapeutic agents in the Suncus murinus: A new experimental model.
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概要
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Acute emetic responses to seven cancer chemotherapeutic agents (adriamycin, bleomycin, cisplatin, cyclophosphamide, 5-fluorouracil, methotrexate, mitomycin C) were studied in the Suncus murinus. Intravenous injection of the drugs caused vomiting with various latency. Cisplatin-induced emesis was prevented by the pretreatment with metoclopramide or chlorpromazine but not with domperidone. These results indicate that the Suncus murinus is a useful animal for testing emetic activities of cancer chemotherapeutics and antiemetic activities of prophylactic drugs.
- 公益社団法人 日本薬理学会の論文
著者
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WANG CHAO-HSIUNG
Chia-nan Junior College of Pharmacy
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Matsuki Norio
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Science The University Of Tokyo
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Saito Hiroshi
Department Of Cardiovascular Medicine Osaka University Graduate School Of Medicine
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UENO Shinya
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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KAJI Takahide
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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ISHIHARA Akane
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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Saito Hiroshi
Department of Applied Chemistry, Graduate School of Engineering, Tohoku University
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