Defect in an Intrahepatic Degradation of Apolipoprotein B in Suncus: An Animal Model of Hypobetalipoproteinemia.
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概要
- 論文の詳細を見る
We have previously shown that fatty liver is easily induced in suncus by starvation and that the plasma level of apolipoprotein B (apo B) is very low. We also found that hepatic acyl coenzyme A cholesterol acyltransferase (ACAT) activity is almost absent in the animals, resulting in decreased cholesteryl ester contents in the liver. A deficiency of cholesteryl ester in suncus liver may be one of the reasons for the defect in the assembly process of apo B-containing lipoproteins, leading to a low level of plasma apo B. Another possible explanation for the induction of fatty liver in suncus is a defect in apo Bprocessing in the liver. In this study, we investigated the hepatic synthetic rate and intrahepatic degradation of apo B using primary cultured hepatocytes derived from suncus and rats. In order to estimate intrahepatic degradation of apo B, we added N-acetylleucylleucynorleucinal to the culture medium as an inhibitor of apo B degradation. The basal synthesis of apo B in suncus hepatocytes was 50% of that in rat. Intracellular degradation of apo B was not observed in suncus hepatocytes, while it was obvious in rat hepatocytes. This evidence suggests that the lower secretion rate of apo B-lipoprotein is not due to the intrahepatic degradation of apo B, but may be due to the low synthetic rate of apo B.
- 社団法人 日本生化学会の論文
著者
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Teramoto Tamio
Department Of Internal Medicine Teikyo University School Of Medicine
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Fujimaki Yuko
Department Of Internal Medicine Teikyo University School Of Medicine
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Liang Yi-qiang
Department Of Gene Diagnostics And Therapeutics Research Institute International Medical Center Of J
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Yamanaka Masami
Department Of Internal Medicine Teikyo University School Of Medicine
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Muto Tomomi
Department Of Internal Medicine Teikyo University School Of Medicine
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Matsuki Norio
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Science The University Of Tokyo
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Saito Hiroshi
Department of Applied Chemistry, Graduate School of Engineering, Tohoku University
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Kinoshita Makoto
Department of Applied Chemistry for Resources, Tokyo University of Agriculture and Technology
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