Antiemetic Effects of Morphine on Motion- and Drug-Induced Emesis in Suncus murinus
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概要
- 論文の詳細を見る
Emetic and antiemetic effects of morphine were investigated in Suncus murinus. Subcutaneous (up to 30 mg/kg) or intracerebroventricular administration (50 μg) of morphine failed to cause emesis. However, pretreatment with morphine (s.c.) prevented the emesis induced by nicotine (10 mg/kg, i.p.), copper sulfate (40 mg/kg, p.o.), cisplatin(20 mg/kg, i.p.) and motion stimulus. These results suggest that morphine has only antiemetic potency and may block a common mechanism for the emetic reflex of suncus, because the antiemetic effects of the drug were exerted irrespective of the stimulus.
- 公益社団法人日本薬学会の論文
- 1997-07-15
著者
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松本 直章
東京大学大学院農学生命科学研究科獣医臨床病理学教室
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SAITO HIROSHI
Department of Neurology, Tohoku University School of Medicine
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MATSUKI Norio
Department of Chemical Pharmacology,Faculty of Pharmaceutical Sciences
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Matsuki Norio
Lab. Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences The Univ. Of Tokyo Jpn
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Matsuki N
Univ. Tokyo Tokyo Jpn
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斉藤 博満
協和発酵・東京研
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Matsuki Norio
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences
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Matsuki Norio
Graduate School Of Pharmaceutical Sciences The University Of Tokyo
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Matsuki Norio
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Science The University Of Tokyo
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Saito H
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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KAKIMOTO Shuichiro
Department of Chemical Pharmacology, Faculty of Pharmaceutical Science, The University of Tokyo
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Kakimoto Shuichiro
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Science The University Of Tokyo
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Saito Hideyuki
Department Of Pharmacology College Of Pharmacy Nihon University
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Saito H
Department Of Pharmacology College Of Pharmacy Nihon University
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Saito Hiroshi
Department Of Cardiovascular Medicine Osaka University Graduate School Of Medicine
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Matsuki Norio
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences The University Of Tok
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Saito Hiroshi
Department of Applied Chemistry, Graduate School of Engineering, Tohoku University
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