Deterioration of Spatial Learning Performances in Lipopolysaccharide-Treated Mice
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概要
- 論文の詳細を見る
It is well demonstrated that acute or chronic stress leads to reduction of learning ability. Lipopolysaccharide (LPS), a component of the outer membrane of gram-negative bacteria, induces profound physiological and behavioral changes, including fever, decrease in food motivation, and decrease in social behavior. These changes might be interpreted as an acute stress reaction to the LPS. In the present study, therefore, we investigated the effects of LPS (400 – 800 μg/kg, i.p.) on spatial learning performances using C57BL/6J male mice. In the Morris water-maze task, spatial learning performances were examined in six trials of training for two consecutive days. LPS-treated mice took a longer time to reach the hidden platform than control mice (F(1,60) = 4.80801, P<0.05 at 600 μg/kg). In addition, injection of LPS decreased the percent of correct choices in the Y-maze test (P<0.05 at 800 μg/kg). LPS, however, did not alter the body weight, grip tone, motor activity or swimming speed. Taken together, these results indicate that LPS treatment specifically impaired spatial learning performances.
- 社団法人 日本薬理学会の論文
- 2001-11-01
著者
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松本 直章
東京大学大学院農学生命科学研究科獣医臨床病理学教室
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IKEGAYA Yuji
Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Science, The University of To
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Ikegaya Yuji
Univ. Tokyo Tokyo
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Ikegaya Yuji
Lab. Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences The Univ. Of Tokyo Jpn
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Ikegaya Yuji
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Science The University Of Toky
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Matsuki Norio
Lab. Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences The Univ. Of Tokyo Jpn
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Matsuki N
Univ. Tokyo Tokyo Jpn
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Matsuki Norio
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences The Universe Of Tokyo
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Matsuki Norio
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences The University Of Tok
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Matsuki Norio
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences
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Matsuki Norio
Graduate School Of Pharmaceutical Sciences The University Of Tokyo
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NISHIYAMA Nobuyoshi
Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of T
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Nishiyama N
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences The Universe Of Tokyo
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Nishiyama Nobuyoshi
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences The University Of Tok
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ARAI Ken
Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The Universe of Tok
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Matsuki Norio
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences The University Of Tok
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Arai Ken
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences The Universe Of Tokyo
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Matsuki Norio
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences The University Of Tok
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Matsuki Norio
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences The University Of Tok
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Matsuki Norio
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences The University Of Tok
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Matsuki Norio
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences The University Of Tok
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池田 友子
Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo
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