ELECTROPHYSIOLOGICAL AND MECHANICAL STUDIES ON THE CARDIAC EFFECTS OF A HISTAMINE H_2 RECEPTOR ANTAGONIST, CIMETIDINE, IN THE ISOLATED GUINEA PIG MYOCARDIUM
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概要
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The effects of cimetidine, a new histamine H_2 receptor antagonist, were studied electrophysiologically and mechanically in the isolated guinea pig myocardium. Cimetidine did not modify the electrical activity of the sinoatrial pacemaker cells at the concentrations up to 10^<-4> M, but depressed the pacemaker potential at the higher concentration, 3×10^<-4> M. Increase in the slope of the pacemaker potential produced by histamine was completely inhibited by cimetidine, indicating that the histamine receptor for the positive chronotropism is of H_2-type. Cimetidine did not depress the maximum rate of rise of the atrial and ventricular action potentials ; thus, unlike most of the H_1 receptor antagonists, cimetidine does not have quinidine like actions. The shape of the action potential was not modified significantly. Slow electrical and mechanical activities produced by histamine in the right ventricular myocardium whose fast Na^+ channels were blocked by elevated external potassium were partially blocked by either cimetidine or diphenhydramine, supporting the view that both types of receptors are present in the right ventricle. Histamine-induced mechanical activity in the depolarized right atrium was inhibited by cimetidine, but that in the left atrium was not inhibited ; these results support the view that the histamine receptor in the left atrium is of H_1-type and suggest that the histamine receptor for the positive inotropism in the right atrium is of H_2-type. In addition, some results were shown suggesting the possibility that cimetidine might have some agonist-like action in the myocardium.
- 公益社団法人日本薬学会の論文
著者
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Matsuki Norio
Lab. Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences The Univ. Of Tokyo Jpn
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Matsuki N
Univ. Tokyo Tokyo Jpn
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Matsuki Norio
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences The Universe Of Tokyo
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Shigenobu Koki
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Matsuki Norio
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences
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Matsuki Norio
Graduate School Of Pharmaceutical Sciences The University Of Tokyo
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Matsuki Norio
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Science The University Of Tokyo
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Kasuya Yutaka
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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TATSUNO HIDEKO
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo
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OSHIMA TAKEYUKI
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo
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Tatsuno Hideko
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Oshima Takeyuki
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Matsuki Norio
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences The University Of Tok
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KASUYA YUTAKA
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo
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