Glibenclamide-Sensitive Hypotension Produced by Helodermin Assessed in the Rat
スポンサーリンク
概要
- 論文の詳細を見る
The effects of helodermin, a basic 35-amino acid peptide isolated from the venom of a lizard salivary gland, on arterial blood pressure and heart rate were examined in the rat, focusing on the possibility that activation of ATP sensitive K^+ (K_<ATP> channels is involved in the responses. The results were also compared with those of vasoactive intestinal polypeptide (VIP). Helodermin produced hypotension in a dose-dependent manner with approximately similar potency and duration to VIP. Hypotension induced by both peptides was significantly attenuated by glibenclamide, which abolished a levcromakalim-produced decrease in arterial blood pressure. Oxyhemoglobin did not affect helodermin-induced hypotension, whereas it shortened the duration of acetylcholine (ACh)-produced hypotension. These findings suggest that helodermin-produced hypotension is partly attributable to the activation of glibenclamide-sensitive K^+ channels (K_<ATP> channels), which presumably exist on arterial smooth muscle cells. EDRF (endothelium-derived relaxing factor)/nitric oxide does not seem to play an important role in the peptide-produced hypotension.
- 公益社団法人日本薬学会の論文
- 1998-12-15
著者
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SHIGENOBU Koki
Department of Pharmacology, Toho University School of
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YANAIHARA Noboru
Laboratory of Bioorganic Chemistry, University Shizuoka, School of Pharmaceutical Sciences
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Shigenobu K
Department Of Pharmacology Toho University School Of Pharmaceutical Sciences
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Shigenobu Koki
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Tanaka Yoshio
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
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Ishii Kunio
Department of Molecular Pharmacology, School of Pharmaceutical Sciences, Kitasato University
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NAKAYAMA Koichi
Department of Molecular and Cellular Pharmacology, Faculty of Pharmaceutical Sciences, Iwate Medical
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Watanabe Nobue
Department of Environmental Health, Tokyo Metropolitan Public Health Research Institute
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Tanaka Yoshio
Dep. Of Chemical Pharmacology Fac. Of Pharmaceutical Sciences Toho Univ.
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Ishii Kunio
Dep. Of Molecular Pharmacology School Of Pharmaceutical Sciences Kitasato Univ.
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Watanabe Nobue
Department Of Pharmacology School Of Pharmaceutical Sciences University Of Shizuoka
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Watanabe Nobue
Department Of Environmental Health Tokyo Metropolitan Public Health Research Institute
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Yanaihara Noboru
Laboratory Of Bioorganic Chemistry School Of Pharmaceutical Sciences University Of Shizuoka
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Nakayama K
Okayama Univ. Okayama Jpn
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Nakayama Koichi
Department Of Molecular And Cellular Pharmacology Faculty Of Pharmaceutical Sciences Iwate Medical U
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HORIKAWA Naotsugu
Department of Pharmacology, School of Pharmaceutical Sciences, University of Shizuoka
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KATAHA Kazuyoshi
Department of Pharmacology, School of Pharmaceutical Sciences, University of Shizuoka
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Kataha Kazuyoshi
Department Of Pharmacology School Of Pharmaceutical Sciences University Of Shizuoka
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Tanaka Yoshio
Department Of Chemical Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Horikawa Naotsugu
Department Of Pharmacology School Of Pharmaceutical Sciences University Of Shizuoka
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Ishii Kunio
Department Of Molecular Pharmacology Kitasato University School Of Pharmaceutical Sciences
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Nakayama Koichi
Department Of Cellular And Molecular Pharmacology Graduate School Of Pharmaceutical Sciences Univers
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Tanaka Yoshio
Department Of Applied Chemistry Faculty Of Engineering Yokohama National University
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YANAIHARA NOBORU
Laboratory of Bio-Organic Chemistry, Shizuoka College of Pharmacy
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