Attenuation of Cataract Progression by A-3922, a Dihydrobenzofuran Derivative, in Streptozotocin-Induced Diabetic Rats(Pharmacology)
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概要
- 論文の詳細を見る
The present study was undertaken to assess whether A-3922, a dihydrobenzofuran derivative that possesses antioxidative effects, had any preventive effect on the onset and/or progression of diabetic cataract. Male Wistar rats were received a bolus intravenous injection of streptozotocin (65mg/kg) and were given 5% glucose in drinking water for 10 weeks. The diabetic rats were divided into two groups and treated with 30mg/kg/d A-3922 or vehicle during the experimental period. The opacities of eye lenses were observed by using both our original device and a slit lamp microscope. The lens opacities were initially detected as early as the 2nd week and the cataracts were developed in similar fashion in both A-3922-treated and untreated diabetic rats until 7th week, suggesting that A-3922 did not show any appreciable effect on the onset of diabetic cataract. In the later period (8th week or later), however, progression of cataract was retarded and significant reductions in both the total cataract score and the degree of opacity were apparently observed on 10th week of A-3922-treated diabetic rats. These results suggest that A-3922 can delay the progression but not the onset of diabetic cataract, and it has a possibility to be a candidate for drugs of cataract associated with diabetes.
- 公益社団法人日本薬学会の論文
- 2008-10-01
著者
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Sakamoto Kenji
Department Of Cardiovascular Medicine Graduate School Of Medical Sciences Kumamoto University
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Sakamoto K
National Inst. Materials Sci. Ibaraki Jpn
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Sakamoto K
Laboratory Of Pharmacology And Toxicology Graduate School Of Pharmaceutical Sciences The University
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MORI ASAMI
Department of Pediatrics, Shiga University Medical Science
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UCHIDA Seiichi
Department of Biological Research, Division 2, Odawara Research Center, Nippon Soda, Co., Ltd.
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Saito Maki
Departments Of Pharmacology Kitasato University School Of Medicine
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Saito Maki
Department Of Molecular And Cellular Pharmacology School Of Pharmaceutical Sciences Iwate Medical Un
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Nakahara Tsutomu
Department of Molecular Pharmacology, School of Pharmaceutical Sciences, Kitasato University
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Ishii Kunio
Department of Molecular Pharmacology, School of Pharmaceutical Sciences, Kitasato University
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Saigo Orie
Department of Molecular Pharmacology, Kitasato University School of Pharmaceutical Sciences, Japan
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UEO Mayumi
Department of Molecular Pharmacology, School of Pharmaceutical Sciences, Kitasato University
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KAMETAKA Sokichi
Department of Molecular Pharmacology, School of Pharmaceutical Sciences, Kitasato University
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HOSAKA Hideo
Department of Biological Research, Division 2, Odawara Research Center, Nippon Soda Co., Ltd.
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Sakamoto Kenji
Research Institute Of Marine Bioresources Fukuyama University
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Ueo Mayumi
Department Of Molecular Pharmacology Kitasato University School Of Pharmaceutical Sciences
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Mori Asami
Department Of Pediatrics Shiga University Medical Science
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Ishii Kunio
Dep. Of Molecular Pharmacology School Of Pharmaceutical Sciences Kitasato Univ.
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Hosaka Hideo
Department Of Biological Research Division 2 Odawara Research Center Nippon Soda Co. Ltd.
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Uchida Seiichi
Department Of Biological Research Division 2 Odawara Research Center Nippon Soda Co. Ltd.
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Nakahara Tsutomu
Dep. Of Molecular Pharmacology School Of Pharmaceutical Sciences Kitasato Univ.
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Nakahara Tsutomu
Department Of Developmental Physiology Institute For Comprehensive Medical Sciences Fujita-gakuen Un
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Sakamoto Kenji
Department Of Advanced Material Science Faculty Of Engineering Kagawa University
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Ishii Kunio
Department Of Molecular Pharmacology Kitasato University School Of Pharmaceutical Sciences
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Sano Misako
Department Of Molecular Pharmacology Kitasato University School Of Pharmaceutical Sciences
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Kametaka Sokichi
Department Of Molecular Pharmacology Kitasato University School Of Pharmaceutical Sciences
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Sakamoto Kenji
Laboratory Of Pharmacology And Toxicology Graduate School Of Pharmaceutical Sciences The University
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Saigo Orie
Department Of Molecular Pharmacology Kitasato University School Of Pharmaceutical Sciences
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Mori Asami
Dep. Of Molecular Pharmacology School Of Pharmaceutical Sciences Kitasato Univ.
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Mori Asami
Department of Molecular Pharmacology, Kitasato University School of Pharmaceutical Sciences, Japan
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Mori Asami
Department of Molecular Pharmacology, Kitasato University School of Pharmaceutical Sciences
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