Inhibition of Untransformed Prostaglandin H2 Production and Stretch-Induced Contraction of Rabbit Pulmonary Arteries by Indoxam, a Selective Secretory Phospholipase A2 Inhibitor
スポンサーリンク
概要
- 論文の詳細を見る
Involvement of secretory phospholipase A2 (sPLA2) in the stretch-induced production of untransformed prostaglandin H2 (PGH2) in the endothelium of rabbit pulmonary arteries was investigated. The stretch-induced contraction was significantly inhibited by indoxam, a selective inhibitor for sPLA2, and NS-398, a selective inhibitor for cyclooxygenase-2 (COX-2). Indoxam inhibited the RGD-sensitive-integrin–independent production of untransformed PGH2, but did not affect the RGD-sensitive-integrin–dependent production of thromboxane A2 (TXA2). These results suggest that the stretch-induced contraction and untransformed PGH2 production was mediated by sPLA2–COX-2 pathway, making it a new possible target for pharmacological intervention of pulmonary artery contractility.
著者
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Sawai Takashi
Department Of Gastroenterology Sendai City Medical Center
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Saito Maki
Departments Of Pharmacology Kitasato University School Of Medicine
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Saito Maki
Department Of Molecular And Cellular Pharmacology School Of Pharmaceutical Sciences Iwate Medical Un
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MORIKAWA Yuki
Department of Biotechnology, Tokyo University of Agriculture and Technology
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Hirose Masamichi
Department of Molecular Pharmacology, Shinshu University School of Medicine
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NAKAYAMA Koichi
Department of Molecular and Cellular Pharmacology, Faculty of Pharmaceutical Sciences, Iwate Medical
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Morikawa Yuki
Department Of Biotechnology Tokyo University Of Agriculture And Technology
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Tanabe Yoshiyuki
Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Iwate Medical
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Kamataki Akihisa
Department of Pathology, School of Medicine, Iwate Medical University, Japan
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Hirose Masamichi
Department Of Molecular Pharmacology Shinshu University School Of Medicine
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Kamataki Akihisa
Department Of Pathology Iwate Medical University School Of Medicine
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Nakayama Koichi
Department Of Cellular And Molecular Pharmacology Graduate School Of Pharmaceutical Sciences Univers
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Hirose Masamichi
Department Of Molecular And Cellular Pharmacology Iwate Medical University School Of Pharmaceutical
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Tanabe Yoshiyuki
Department Of Molecular And Cellular Pharmacology School Of Pharmaceutical Sciences Iwate Medical Un
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