Clinicopathological Study on Endocrine Cell Micronests Associated with Early Gastric Cancer
スポンサーリンク
概要
- 論文の詳細を見る
Objective The purpose of this study was to review cases of early gastric cancer associated with Endocrine cell micronests (ECM) and investigate the incidence and characteristics of these lesions. Methods A total of 482 patients who had undergone endoscopic or surgical resection for gastric epithelial neoplasms from April 2008 to March 2010 were enrolled in this study. After detection of ECM in the lamina propria mucosa by histological examination of the resected specimens with hematoxilin-eosin staining, immunostaining was also performed. Clinical manifestation and endoscopic findings, as well as histological findings, were examined. Results Among the 482 patients, 5 (1.0%) had ECM. The histological type of gastric epithelial cancers associated with ECM was tubular adenocarcinoma and carcinoma in situ (Tis) in the WHO classification in all 5 cases. ECM were round to oval or trabecular and located within the area of the early gastric cancer in all the 5 cases. The background gastric mucosa was Type A gastritis in 2 patients and ordinary atrophic gastritis in 2 patients. In the other case, it was difficult to determine the type of gastritis. Conclusion ECM developed not only from the background of Type A gastritis but also from ordinary atrophic gastritis. ECM coexistent with gastric cancer were present in 1.0% of resectable gastric epithelial neoplasms.
著者
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Sawai Takashi
Department Of Gastroenterology Sendai City Medical Center
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Noda Yutaka
Department Of Gastroenterology Sendai City Medical Center
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Sugawara Toshiki
Department Of Gastroenterology Sendai City Medical Center
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Fujita Naotaka
Department Of Gastroenterology Sendai City Medical Center
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Harada Yoshihiro
Department Of Gastroenterology Sendai City Medical Center
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Hirasawa Dai
Department Of Gastroenterology Sendai City Medical Center
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Ohira Tetsuya
Department Of Gastroenterology Sendai City Medical Center
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Obana Takashi
Department Of Gastroenterology Sendai City Medical Center
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Kurose Akira
Department Of Pathology I School Of Medicine Iwate Medical University
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Suzuki Kenjiro
Department Of Machinery And Control Systems Shibaura Institute Of Technology
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Maeda Yuki
Department Of Applied Chemistry Graduate School Of Engineering Kyushu University
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Tanaka Megumi
Department Of Bioengineering Nagaoka University Of Technology
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Yamagata Taku
Department of Gastroenterology, Sendai City Medical Center, Japan
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Koike Yoshiki
Department of Gastroenterology, Sendai City Medical Center, Japan
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Kusaka Jun
Department of Gastroenterology, Sendai City Medical Center, Japan
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Suzuki Kenjiro
Department of Gastroenterology, Sendai City Medical Center, Japan
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Hirasawa Dai
Department of Gastroenterology, Sendai City Medical Center, Japan
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Ohira Tetsuya
Department of Gastroenterology, Sendai City Medical Center, Japan
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Ohira Tetsuya
Department of Epidemiology, Radiation Medical Center for the Fukushima Health Management Survey, Fukushima Medical University
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Sawai Takashi
Department of Pathology, Iwate Medical University, Japan
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