Botulinum Neurotoxin A Blocks Cholinergic Ganglionic Neurotransmission in the Dog Heart
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概要
- 論文の詳細を見る
There is no data about whether botulinum neurotoxin inhibits the parasympathetic ganglionic neurotransmission in the heart, although botulinum toxin as a clinical drug inhibits the release of acetylcholine at the neuromuscular junction. Therefore, we investigated whether botulinum toxin (type A) injected into the sinoatrial (SA) fat pad inhibits decreases in heart rate induced by stimulation of the preganglionic parasympathetic nerves in the heart of the anesthetized dog. Stimulation of the parasympathetic nerves in the SA fat pad (SAP stimulation) prolonged the atrial interval but not the atrioventricular (AV) interval, and cervical vagus nerve stimulation (CV stimulation) prolonged both atrial and AV intervals. After botulinum toxin (20 or 25 mouse units) was injected into the SA fat pad, it gradually inhibited the prolongation of the atrial interval evoked by SAP and CV stimulations but not the prolongation of the AV interval evoked by CV stimulation. Conditioning successive stimulation of the cervical vagus nerves accelerated the inhibition by botulinum toxin of the chronotropic response to CV stimulation. These results indicate that selective injection of botulinum toxin into the SA fat pad blocks bradycardia mediated by parasympathetic ganglionic activation in the dog heart.
- 社団法人 日本薬理学会の論文
- 2002-07-01
著者
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TSUBOI Masato
Department of Astronomy, School of Science, The University of Tokyo
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TSUBOI Masato
Institute of Astrophysics and Planetary Science, Ibaraki University
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Chiba Shigetoshi
Department Of Molecular Pharmacology Shinshu University School Of Medicine
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Hirose Masamichi
Department of Molecular Pharmacology, Shinshu University School of Medicine
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NAKAJIMA Koichi
Department of Immunology, Osaka City University Graduate School of Medicine
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Tsuboi M
Institute Of Astrophysics And Planetary Science Ibaraki University
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Kurogouchi Fumio
Department Of Pharmacology Shinshu University School Of Medicine
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FURUKAWA Yasuyuki
Department of Pharmacology, Shinshu University School of Medicine
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Furukawa Yasuyuki
Department Of Pharmacology Shinshu University School Of Medicine
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Chiba S
信州大学 薬理
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Hirose Masamichi
Department Of Pharmacology Shinshu University School Of Medicine
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Hirose Masamichi
Department Of Molecular Pharmacology Shinshu University School Of Medicine
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Nakajima Koichi
Department Of Pharmacology Shinshu University School Of Medicine
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Nakajima Koichi
Department Of Immunology Osaka City University Graduate School Of Medicine
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Hirose Masamichi
Department Of Molecular And Cellular Pharmacology Iwate Medical University School Of Pharmaceutical
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Chiba Shigetoshi
Departmen T Of Pharmacology Shinshu University School Of Medicine
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Tsuboi Masato
Department Of Astronomy School Of Science The University Of Tokyo
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