Neuroeffector Mechanisms Involved in the Regulation of Dog Splenic Arterial Tone
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概要
- 論文の詳細を見る
It has been recognized that sympathetic neurons release several transmitters but mainly adenosine 5-triphosphate (ATP), noradrenaline, and neuropeptide Y (NPY). Recently, we reported that periarterial nerve electrical stimulation (PNS) produced biphasic vasoconstrictions consisting of an initial transient, predominantly P2X-purinoceptor-mediated constriction followed by a prolonged, α1-adrenoceptor-mediated one in canine isolated splenic arteries. In this article, we tried to analyze the effects of several selective key drugs that influence the PNS-induced responses, and we functionally showed sympathetic transmitter releasing mechanisms by pharmacological analysis using purinergic, adrenergic, and NPYergic agonists and antagonists.
- 社団法人 日本薬理学会の論文
- 2003-06-01
著者
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Yang Xiao-ping
Department Of Molecular Pharmacology Shinshu University School Of Medicine
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Yang Xiao-ping
Department Of Pharmacology Shinshu University School Of Medicine
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Chiba Shigetoshi
Department Of Molecular Pharmacology Shinshu University School Of Medicine
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Yang Xiao-ping
Departmen T Of Pharmacology Shinshu University School Of Medicine
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Chiba S
Department Of Pharmacology Shinshu University School Of Medicine
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Chiba Shigetoshi
Departmen T Of Pharmacology Shinshu University School Of Medicine
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