Absence of blocking effect of burimamide and metiamide on positive chronotropic and inotropic responses to histamine in isolated dog atrium.
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When histamine was injected into the sinus node artery of isolated dog atrium perfused with arterial blood led from a carotid artery of the heparinized support dog, positive chronotropic and inotropic effects were dose-relatedly induced at a dose range of 0.1 to 100 μg. The threshold dose for inducing these positive effects was approximately 0.3 μg. These positive responses to histamine were not blocked by tetrodotoxin, desmethylimipramine and alprenolol. These positive effects of histamine were also not significantly influenced by treatment with a histamine H<SUB>2</SUB> receptor antagonist, burimamide or metiamide. However, these histamine-induced positive chronotropic and inotropic effects were significantly suppressed by an adequate dose of histamine H<SUB>1</SUB> receptor antagonist, tripelennamine or diphenhydramine, which enhanced the actions of norepinephrine. From these results, it is suggested that in the dog atrium, histamine causes positive chronotropic and inotropic effects <I>via</I> histamine H<SUB>1</SUB> receptors.
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