A Negative Inotropic Effect of Omega-Conotoxin GVIA in Isolated, Blood-Perfused Dog Right Atria.
スポンサーリンク
概要
- 論文の詳細を見る
Using an isolated, blood-perfused canine atrial preparation, we investigated the effects of omega-conotoxin GVIA (omega-CgTX), a blocker of N-type voltage-operated calcium channels, on the atrial contractile force and sinus rate. Omega-CgTX in a dose range of 0.3-3 nmol gradually attenuated the atrial contractile force in a dose-dependent manner, but did not affect the sinus rate, indicating that it can depress contractility but not pacemaker activity.
著者
-
KARASAWA Yasuyuki
Department of Internal Medicine 2, Sinshu University Medical School
-
Furukawa Yasuyuki
Department Of Pharmacology Shinshu University School Of Medicine
-
Murakami Makoto
Department Of Agricultural Engineering Faculty Of Agriculture Hokkaido University
-
Takayama Shin
Department Of Medical Oncology Cancer Institute Hospital Japanese Foundation For Cancer Research
-
Chiba Shigetoshi
Departmen T Of Pharmacology Shinshu University School Of Medicine
-
REN Lei-Ming
Department of Pharmacology, Shinshu University School of Medicine
-
Inoue Yasurou
Department of Pharmacology, Shinshu University School of Medicine
-
Sawaki Shoji
Department of Pharmacology, Shinshu University School of Medicine
関連論文
- Induction of PYPAF1 during In Vitro Maturation of Mouse Mast Cells
- Papyriflavonol A from Broussonetia papyrifera Inhibits the Passive Cutaneous Anaphylaxis Reaction and Has a Secretory Phospholipase A_2-Inhibitory Activity
- Extracorporeal shock wave lithotripsy of pancreatic duct stones and patient factors related to stone disintegration
- Insulin and Somatostatin Releasing Islet Cell Tumor Caused Hypoglycemia
- Duodenal Somatostatinoma and Erythrocytosis in a Patient with Von Hippel-Lindau Disease Type 2A
- Reassessment of K-ras Mutations at Codon 12 by Direct PCR and Sequencing from Tissue Microdissection in Human Pancreatic Adenocarcinomas
- Characterization of Heparin Low-Affinity Phospholipase A_1 Present in Brain and Testicular Tissue
- Sentinel Lymph Node Biopsy Using Tin Colloid RI and Blue Dye Method
- Phospholipase A_2
- Lipomatous Hypertrophy of the Interatrial Septum With Cutaneous Lipomatosis
- Periarterial Electrical Nerve Stimulation-Induced Adrenergic Vasoconstriction Inhibited by Adrenergic α_-Receptor Blockade but Not by α_-Blockade
- Different Sensitivities to α_1 Adrenoceptor Blockade on Periarterial Sympathetic Nerve-Induced Constriction by Low and High Frequencies in Canine Isolated Splenic Arteries
- Effects of Imipramine, an Uptake Inhibitor, on Double-Peaked Constrictor Responses to Periarterial Nerve Stimulation in Isolated, Per fused Canine Splenic Arteries
- Effects of Prolonged Cold Storage on Purinergic and Adrenergic Components of Sympathetic Co-transmission in Isolated Canine Splenic Arteries
- Neuroeffector Mechanisms Involved in the Regulation of Dog Splenic Arterial Tone
- Perivascular Purinergic Nerve-Induced Vasoconstrictions in Canine Isolated Splenic Arteries
- Effects of Neuropeptide Y on Double-Peaked Constrictor Responses to Periarterial Nerve Stimulation in Isolated, Perfused Canine Splenic Arteries
- Lysophosphatidylserine Enhances Exogenous Type II Phospholipase A_2-Induced Activation of Rat Serosal Mast Cells
- Gene Expression of MASH-1, MATH-1, neuroD and NSCL-2, Basic Helix-Loop-Helix Proteins, during Neural Differentiation in P19 Embryonal Carcinoma Cells
- Botulinum Neurotoxin A Blocks Cholinergic Ganglionic Neurotransmission in the Dog Heart
- A Na^+/Ca^ Exchanger Inhibitor, KB-R7943, Caused Negative Inotropic Responses and Negative Followed by Positive Chronotropic Responses in Isolated, Blood-Perfused Dog Heart Preparations
- Propofol decreases contractility of isolated blood-perfused left ventricular muscle in the dog
- Cardiac effects of propofol and its interaction with autonomic nervous system in isolated, cross-circulated canine atria
- Effects of Low Temperature on the Chronotropic and Inotropic Responses to Zatebradine, E-4031 and Verapamil in Isolated Per fused Dog Atria
- Different Chronotropic and Inotropic Effects of EMD 57033 and EMD 53998, Ca^ Sensitizers, on Isolated, Blood-Perfused Dog Heart Preparations
- Inhibition of Delayed Rectifier K^+ Current by Dofetilide and E-4031 Differentially Affects Electrical Cardiac Responses to Vagus Stimulation in Anesthetized Dogs
- Negative Chronotropic and Inotropic Effects of U-92032, a Novel T-Type Ca^ Channel Blocker, on the Isolated, Blood-Perfused Dog Atrium
- Differences in α_1-Adrenoceptor Subtype-Mediated Vasoconstriction by Tyramine and Nerve Stimulation in Canine Splenic Artery
- Association of N-myc Downregulated Gene 1 with Heat-Shock Cognate Protein 70 in Mast Cells (Biochemistry/Molecular Biology)
- N-Myc Downregulated Gene 1 Is a Phosphorylated Protein in Mast Cells (Biochemistry/Molecular Biology)
- Alkalinization-Induced K^+ Current of the Mouse Megakaryocyte
- Dissociation of Potentiation of Leu^ Pro^ Neuropeptide Y on Adrenergic and Purinergic Transmission in Isolated Canine Splenic Artery
- Effects of Magnesium on the Isolated, Blood-Perfused Atrial and Ventricular Preparations of the Dog Heart
- MECHANISM OF POSITIVE CHRONOTROPIC AND INOTROPIC EFFECTS INDUCED BY 4-METHYLHISTAMINE
- Chronotropic and Inotropic Effects of Bradykinin on Isolated, Blood-perfused Canine Atrium
- Effects of Temperature on Inotropic Responses of Isolated Canine Atria under Spontaneous or Electrically Paced Rhythm
- A Pharmacologic Analysis of Chronotropic and Inotropic Responses to Direct Electrical Stimulation of the Isolated, Blood-perfused. Canine Atrium
- Cardiac Arrest and Reactivation by Changes of Temperature in the Isolated, Blood-perfused Canine Heart
- Absence of Acute Cardiac Effect of Triiodothyronine in Isolated, Blood-perfused Canine Atrium
- EFFECT OF NIFEDIPINE ON FREQUENCY-FORCE RELATIONSHIP IN ISOLATED DOG LEFT VENTRICULAR MUSCLE
- POTENTIATION OF TYRAMINE ACTION BY 5-HYDROXYTRYPTAMINE IN THE DOG HEART
- Effects of Cardioactive Substances on the Post-stimulation Potentiation of Contractility in the Isolated Dog Atrium
- Effects of Optical Isomers of Verapamil on SA Nodal Pacemaker Activity and Contractility of the Isolated Dog Heart
- Direct Positive Chronotropic and Inotropic Effects of Ouabain in the Isolated and Blood-Perfused Canine Atrium
- CHRONOTROPIC RESPONSES TO LARGE DOSES OF ADENOSINE AND ATP IN DOG ISOLATED ATRIA
- DOUBLE-PEAKED POSITIVE CHRONOTROPIC RESPONSES OF ISOLATED AND CROSS-PERFUSED DOG ATRIA TO ATP
- Direct Effects of Digoxin and Deslanoside on Sinoatrial Conduction in Isolated, Blood-perfused Dog Atria
- ANALYSIS OF APPLE QUALITY BY NEAR INFRARED REFLECTANCE SPECTROSCOPY : Measurement of moisture, sugar and apple acid content in different varieties using a single calibration equation
- ANALYSIS OF PUMPKIN QUALITY BY NEAR-INFRARED REFLECTANCE SPECTROSCOPY
- Acute Desensitization of Adenosine by Adenosine Infusion in Isolated Dog Atria
- Dominant Anti-vagal Effect of Pentobarbital on Cardiac Responses to Intracardiac Autonomic Nerve Stimulation in the Dog
- Efficient Production of Cellulolytic and Xylanolytic Enzymes by the Rumen Anaerobic Fungus, Neocallimastix frontalis, in a Repeated Batch Culture
- Cardiovascular Effects of Aminophylline and Pentoxifylline on Intact Dogs and Isolated Dog Atria
- EFFECTS OF IMIPRAMINE ON FREQUENCY-FORCE RELATIONSHIP IN ISOLATED RIGHT ATRIAL MUSCLE OF THE DOG
- EFFECTS OF NICARDIPINE ON THE CROSS-PERFUSED CANINE ATRIUM
- Cardiovascular Effects of Imipramine in Intact Dogs and Isolated Dog Atria
- Analysis of Cardiac Actions of Nitroprusside in Intact Dogs and in Isolated Atria
- Chronotropic and Inotropic Effects of Captopril on the Dog Heart
- CARDIAC STIMULATING EFFECTS OF MACROCYCLIC POLYAMINES
- EFFECT OF ADENOSINE ON THE FREQUENCY-FORCE RELATIONSHIP IN THE ISOLATED DOG ATRIUM
- COMPARISON OF THE EFFECTS OF NOREPINEPHRINE AND ACETYLCHOLINE BETWEEN INTRAARTERIAL AND EXTRAVASCULAR ADMINISTRATION TO THE ISOLATED, BLOOD-PERFUSED CANINE ATRIUM
- Secretory Phospholipase A_2(Diversity of Phospholipase A_2 Enzymes)
- Differences in Chronotropic and Inotropic Responses of Canine Atrial Muscle and SA Node Pacemaker Activity to Adenosine and ACh
- HUMAN MOTION AND SPEECH ANALYSIS TO CONSTRUCT DECISION MODEL FOR A ROBOT TO END COMMUNICATING WITH A HUMAN(International Workshop on Advanced Image Technology 2009)
- Epidemiology of human papillomavirus genotypes in pregnant Japanese women
- Cardiac effects of YM-09538, a new .ALPHA.- and .BETA.-adrenoceptor blocking agent, on SA nodal pacemaker activity and contractility in isolated atria and intact dogs.
- Chronotropic and inotropic effects of 3 kinds of alpha-adrenergic blockers on the isolated dog atria.
- Postjunctional .ALPHA.1- and .ALPHA.2-Adrenoceptors in Cat Forepaw Vasculature.
- Sympathetic Nerve Stimulation Activates Both .BETA.1- and .BETA.2- Adrenoceptors of SA and AV Nodes in Anesthetized Dog Hearts.
- A Negative Inotropic Effect of Omega-Conotoxin GVIA in Isolated, Blood-Perfused Dog Right Atria.
- Pharmacological analysis of positive chrono- and inotropic responses to denopamine (TA-064) in dog cross-circulated atrial and ventricular preparations.
- Cardiovascular effects of 2-amino-N-(2,6-dimethylphenyl)-N-(3-(3-pyridyl)propyl)propionamide dihydrochloride(Ro 22-9194) in the isolated, cross-perfused atrium of the dog.
- Pharmacological analysis of cardiac effects of a central cholinergic agent, WEB 1881-FU, in isolated canine heart preparations.
- Cardiovascular responses to a newly developed phosphodiesterase inhibitor, DN-9693 (7-pyperidinyl-1,2,3,5-tetrahydroimidazo (2,1-b)-quinazolin-2-oneHCl) in dog cross-circulated atrial and ventricular preparations.
- Direct chronotropic and inotropic effects of mildronate using cross-circulated dog atrial and ventricular preparations.
- Cardiovascular effects of methylflavonolamine hydrochloride(SIPI-549) in cross-circulated canine atrial and ventricular preparations.
- Adenosine-guanosine interactions in the isolated dog atrium.
- Anti-Nicotinic and Anti-Muscarinic Actions of Eperisone in the Isolated Canine Atrium.
- Chronotropic and inotropic effects of a new angiotensin converting enzyme inhibitor, MC-838(altiopril calcium), on the dog heart.
- Cardiovascular effects of dibutyryl cyclic AMP in the intact dog heart and the isolated cross-perfused right atrium.
- Cardiovascular effects of a new phenoxyalkylamine derivative, 2-isopropyl-5-(3-(2-methoxyphenoxy)propylamino)-2-(3,4,5-trimethoxyphenyl)valeronitrile fumarate (HV-525), in cross-circulated dog atrial preparations.
- Suppression of strychnine on the chronotropic and inotropic effects in the isolated, blood-perfused canine atrium.
- Positive inotropic and negative chronotropic effects of OPC-8490, a newly developed cardiotonic, in isolated, blood-perfused canine heart preparations.
- Differential intracardiac sympathetic and parasympathetic innervation to the SA and AV nodes in anesthetized dog hearts.
- Chronotropic, dromotropic and inotropic effects of dilazep in the intact dog heart and isolated atrial preparation.
- Cardiovascular responses to a newly developed cardiotonic agent, ZSY-39 (4-methyl-5-(4-pyridinyl)-thiazole-2-carboxyamide) in dog cross-circulated atrial and ventricular preparations.
- Cardiovascular effects of budralazine in the dog.
- Comparative study of cardiovascular effects of clonidine and alinidine in cross-perfused dog atrial preparations.
- Predominant negative inotropic effect of UTP on dog cardiac muscle.
- Inotropic and chronotropic activity of a new cardiotonic agent, DM 9278 (1,2,3,4,8,9,10,12-octahydro(2,1-b)pyrido(2,3-f)qunazolin-9-one), on isolated dog atrial and ventricular muscles.
- Ouabain-induced negative frequency-force relationship in the isolated, blood-perfused dog atrium.
- Negative chronotropic and positive inotropic effects of a unique cardioactive agent, N,N'-dicyclopropyl methyl piperazine(bis) hydrochloride(INO 2628), in isolated, blood-perfused dog atria.
- Cardiovascular effects of ZSY-27 (5-methyl-6-(4-pyridinyl)-2H-1,4-thiazine-3(4H)-onehydrochloride) in the dog cross-circulated atrial preparation.
- Different effectiveness of glucagon on the pacemaker activity and contractility in intact dog hearts and in isolated perfused right atria.
- Bradycardic effects of AQ-A 39(falipamil) in situ and in isolated, blood-perfused dog hearts comparison with alinidine and verapamil.:Comparison with Alinidine and Verapamil
- Cardiac effects of piretanide and furosemide on intact anesthetized dogs and on isolated atria.
- Pinacidil Attenuates Positive Inotropic but Not Chronotropic Responses to Norepinephrine in Isolated Dog Atrial and Venbtricular Preparations.
- Effects of Glibenclamide on Negative Cardiac Responses to Cholinerg and Purinergic Stimuli and Cromakalim in the Isolated Dog Heart.
- Hot Topics in Phospholipase A_2 Field(Diversity of Phospholipase A_2 Enzymes)
- Induction of PYPAF1 during In Vitro Maturation of Mouse Mast Cells