Pinacidil Attenuates Positive Inotropic but Not Chronotropic Responses to Norepinephrine in Isolated Dog Atrial and Venbtricular Preparations.
スポンサーリンク
概要
- 論文の詳細を見る
We investigated whether pinacidil, a K<SUP>+</SUP><SUB>ATP</SUB> channel opener like acetylcholine and adenosine, attenuated the positive chronotropic and inotropic responses to norepinephrine in isolated, blood-perfused dog atrial and ventricular preparations. Pinacidil (0.01-0.3 μmol) decreased atrial and ventricular contractile force to a much greater extent than sinus rate in a dose-related manner. Pinacidil dose-dependently attenuated increases in atrial and ventricular forces induced by norepinephrine but not increases in sinus rate. Pinacidil similarly attenuated the positive atrial and ventricular inotropic responses to Bay k 8644 and CaCl<SUB>2</SUB>. The pinacidil doses producing a fifty percent decrease (ED<SUB>50</SUB>) of the atrial and ventricular contractile force were not significantly different from the respective pinacidil doses producing a fifty percent inhibition (ID<SUB>50</SUB>) of the positive inotropic responses to norepinephrine, Bay k 8644 and CaCl<SUB>2</SUB>. Ouabain (5 and 15 nmol) did not affect the decreases in atrial and ventricular contractile force in response to pinacidil. These results suggest that the K<SUP>+</SUP><SUB>ATP</SUB>-channel activator pinacidil, unlike acetylcholine or adenosine, functionally attenuates increases in ventricular and atrial contractile force in the responses to norepinephrine and other cardiotonics due to shortening of the action potential duration induced by K<SUP>+</SUP><SUB>ATP</SUB>-channel activation in the dog heart.
- 公益社団法人 日本薬理学会の論文
著者
-
Furukawa Yasuyuki
Department Of Pharmacology Shinshu University School Of Medicine
-
Murakami Makoto
Department Of Agricultural Engineering Faculty Of Agriculture Hokkaido University
-
Takayama Shin
Department Of Medical Oncology Cancer Institute Hospital Japanese Foundation For Cancer Research
-
Chiba Shigetoshi
Departmen T Of Pharmacology Shinshu University School Of Medicine
-
Takayama Shin
Department of Pharmacology, Shinshu University School of Medicine
関連論文
- Induction of PYPAF1 during In Vitro Maturation of Mouse Mast Cells
- Papyriflavonol A from Broussonetia papyrifera Inhibits the Passive Cutaneous Anaphylaxis Reaction and Has a Secretory Phospholipase A_2-Inhibitory Activity
- Characterization of Heparin Low-Affinity Phospholipase A_1 Present in Brain and Testicular Tissue
- Sentinel Lymph Node Biopsy Using Tin Colloid RI and Blue Dye Method
- Phospholipase A_2
- Lipomatous Hypertrophy of the Interatrial Septum With Cutaneous Lipomatosis
- Periarterial Electrical Nerve Stimulation-Induced Adrenergic Vasoconstriction Inhibited by Adrenergic α_-Receptor Blockade but Not by α_-Blockade
- Different Sensitivities to α_1 Adrenoceptor Blockade on Periarterial Sympathetic Nerve-Induced Constriction by Low and High Frequencies in Canine Isolated Splenic Arteries
- Effects of Imipramine, an Uptake Inhibitor, on Double-Peaked Constrictor Responses to Periarterial Nerve Stimulation in Isolated, Per fused Canine Splenic Arteries
- Effects of Prolonged Cold Storage on Purinergic and Adrenergic Components of Sympathetic Co-transmission in Isolated Canine Splenic Arteries
- Neuroeffector Mechanisms Involved in the Regulation of Dog Splenic Arterial Tone
- Perivascular Purinergic Nerve-Induced Vasoconstrictions in Canine Isolated Splenic Arteries
- Effects of Neuropeptide Y on Double-Peaked Constrictor Responses to Periarterial Nerve Stimulation in Isolated, Perfused Canine Splenic Arteries
- Lysophosphatidylserine Enhances Exogenous Type II Phospholipase A_2-Induced Activation of Rat Serosal Mast Cells
- Gene Expression of MASH-1, MATH-1, neuroD and NSCL-2, Basic Helix-Loop-Helix Proteins, during Neural Differentiation in P19 Embryonal Carcinoma Cells
- Botulinum Neurotoxin A Blocks Cholinergic Ganglionic Neurotransmission in the Dog Heart
- A Na^+/Ca^ Exchanger Inhibitor, KB-R7943, Caused Negative Inotropic Responses and Negative Followed by Positive Chronotropic Responses in Isolated, Blood-Perfused Dog Heart Preparations
- Propofol decreases contractility of isolated blood-perfused left ventricular muscle in the dog
- Cardiac effects of propofol and its interaction with autonomic nervous system in isolated, cross-circulated canine atria
- Effects of Low Temperature on the Chronotropic and Inotropic Responses to Zatebradine, E-4031 and Verapamil in Isolated Per fused Dog Atria
- Different Chronotropic and Inotropic Effects of EMD 57033 and EMD 53998, Ca^ Sensitizers, on Isolated, Blood-Perfused Dog Heart Preparations
- Inhibition of Delayed Rectifier K^+ Current by Dofetilide and E-4031 Differentially Affects Electrical Cardiac Responses to Vagus Stimulation in Anesthetized Dogs
- Negative Chronotropic and Inotropic Effects of U-92032, a Novel T-Type Ca^ Channel Blocker, on the Isolated, Blood-Perfused Dog Atrium
- Differences in α_1-Adrenoceptor Subtype-Mediated Vasoconstriction by Tyramine and Nerve Stimulation in Canine Splenic Artery
- Association of N-myc Downregulated Gene 1 with Heat-Shock Cognate Protein 70 in Mast Cells (Biochemistry/Molecular Biology)
- N-Myc Downregulated Gene 1 Is a Phosphorylated Protein in Mast Cells (Biochemistry/Molecular Biology)
- Alkalinization-Induced K^+ Current of the Mouse Megakaryocyte
- Dissociation of Potentiation of Leu^ Pro^ Neuropeptide Y on Adrenergic and Purinergic Transmission in Isolated Canine Splenic Artery
- Effects of Magnesium on the Isolated, Blood-Perfused Atrial and Ventricular Preparations of the Dog Heart
- MECHANISM OF POSITIVE CHRONOTROPIC AND INOTROPIC EFFECTS INDUCED BY 4-METHYLHISTAMINE
- Chronotropic and Inotropic Effects of Bradykinin on Isolated, Blood-perfused Canine Atrium
- Effects of Temperature on Inotropic Responses of Isolated Canine Atria under Spontaneous or Electrically Paced Rhythm
- A Pharmacologic Analysis of Chronotropic and Inotropic Responses to Direct Electrical Stimulation of the Isolated, Blood-perfused. Canine Atrium
- Cardiac Arrest and Reactivation by Changes of Temperature in the Isolated, Blood-perfused Canine Heart
- Absence of Acute Cardiac Effect of Triiodothyronine in Isolated, Blood-perfused Canine Atrium
- EFFECT OF NIFEDIPINE ON FREQUENCY-FORCE RELATIONSHIP IN ISOLATED DOG LEFT VENTRICULAR MUSCLE
- POTENTIATION OF TYRAMINE ACTION BY 5-HYDROXYTRYPTAMINE IN THE DOG HEART
- Effects of Cardioactive Substances on the Post-stimulation Potentiation of Contractility in the Isolated Dog Atrium
- Effects of Optical Isomers of Verapamil on SA Nodal Pacemaker Activity and Contractility of the Isolated Dog Heart
- Direct Positive Chronotropic and Inotropic Effects of Ouabain in the Isolated and Blood-Perfused Canine Atrium
- CHRONOTROPIC RESPONSES TO LARGE DOSES OF ADENOSINE AND ATP IN DOG ISOLATED ATRIA
- DOUBLE-PEAKED POSITIVE CHRONOTROPIC RESPONSES OF ISOLATED AND CROSS-PERFUSED DOG ATRIA TO ATP
- Direct Effects of Digoxin and Deslanoside on Sinoatrial Conduction in Isolated, Blood-perfused Dog Atria
- ANALYSIS OF APPLE QUALITY BY NEAR INFRARED REFLECTANCE SPECTROSCOPY : Measurement of moisture, sugar and apple acid content in different varieties using a single calibration equation
- ANALYSIS OF PUMPKIN QUALITY BY NEAR-INFRARED REFLECTANCE SPECTROSCOPY
- Acute Desensitization of Adenosine by Adenosine Infusion in Isolated Dog Atria
- Dominant Anti-vagal Effect of Pentobarbital on Cardiac Responses to Intracardiac Autonomic Nerve Stimulation in the Dog
- Efficient Production of Cellulolytic and Xylanolytic Enzymes by the Rumen Anaerobic Fungus, Neocallimastix frontalis, in a Repeated Batch Culture
- Cardiovascular Effects of Aminophylline and Pentoxifylline on Intact Dogs and Isolated Dog Atria
- EFFECTS OF IMIPRAMINE ON FREQUENCY-FORCE RELATIONSHIP IN ISOLATED RIGHT ATRIAL MUSCLE OF THE DOG
- EFFECTS OF NICARDIPINE ON THE CROSS-PERFUSED CANINE ATRIUM
- Cardiovascular Effects of Imipramine in Intact Dogs and Isolated Dog Atria
- Analysis of Cardiac Actions of Nitroprusside in Intact Dogs and in Isolated Atria
- Chronotropic and Inotropic Effects of Captopril on the Dog Heart
- CARDIAC STIMULATING EFFECTS OF MACROCYCLIC POLYAMINES
- EFFECT OF ADENOSINE ON THE FREQUENCY-FORCE RELATIONSHIP IN THE ISOLATED DOG ATRIUM
- COMPARISON OF THE EFFECTS OF NOREPINEPHRINE AND ACETYLCHOLINE BETWEEN INTRAARTERIAL AND EXTRAVASCULAR ADMINISTRATION TO THE ISOLATED, BLOOD-PERFUSED CANINE ATRIUM
- Secretory Phospholipase A_2(Diversity of Phospholipase A_2 Enzymes)
- Differences in Chronotropic and Inotropic Responses of Canine Atrial Muscle and SA Node Pacemaker Activity to Adenosine and ACh
- HUMAN MOTION AND SPEECH ANALYSIS TO CONSTRUCT DECISION MODEL FOR A ROBOT TO END COMMUNICATING WITH A HUMAN(International Workshop on Advanced Image Technology 2009)
- EFFECTS OF CYCLIC GMP ON THE SECRETION OF PANCREATIC JUICE IN THE BLOOD-PERFUSED CANINE PANCREAS
- Existence of Functional α_- and α_- but No α_-Adrenoceptor Subtypes in Rat Common Carotid Arteries
- Effects of Temperature on Norepinephrine-Induced Sinus Acceleration and Overdrive Suppression in the Isolated Dog Atrium
- Pharmacologic Analysis of Stretch-Induced Sinus Acceleration of the Isolated Dog Atrium
- EFFECTS OF METHYLISOBUTYLXANTHINE (MIX) ON THE SECRETION OF PANCREATIC JUICE IN THE BLOOD-PERFUSED CANINE PANCREAS
- POTENTIATING EFFECTS OF DIPYRIDAMOLE ON THE SECRETION OF PANCREATIC JUICE INDUCED BY SECRETIN IN THE BLOOD-PERFUSED DOG PANCREAS
- Epidemiology of human papillomavirus genotypes in pregnant Japanese women
- Cardiac effects of YM-09538, a new .ALPHA.- and .BETA.-adrenoceptor blocking agent, on SA nodal pacemaker activity and contractility in isolated atria and intact dogs.
- Chronotropic and inotropic effects of 3 kinds of alpha-adrenergic blockers on the isolated dog atria.
- Sympathetic Nerve Stimulation Activates Both .BETA.1- and .BETA.2- Adrenoceptors of SA and AV Nodes in Anesthetized Dog Hearts.
- A Negative Inotropic Effect of Omega-Conotoxin GVIA in Isolated, Blood-Perfused Dog Right Atria.
- Pharmacological analysis of positive chrono- and inotropic responses to denopamine (TA-064) in dog cross-circulated atrial and ventricular preparations.
- Cardiovascular effects of 2-amino-N-(2,6-dimethylphenyl)-N-(3-(3-pyridyl)propyl)propionamide dihydrochloride(Ro 22-9194) in the isolated, cross-perfused atrium of the dog.
- Cardiovascular responses to a newly developed phosphodiesterase inhibitor, DN-9693 (7-pyperidinyl-1,2,3,5-tetrahydroimidazo (2,1-b)-quinazolin-2-oneHCl) in dog cross-circulated atrial and ventricular preparations.
- Direct chronotropic and inotropic effects of mildronate using cross-circulated dog atrial and ventricular preparations.
- Cardiovascular effects of methylflavonolamine hydrochloride(SIPI-549) in cross-circulated canine atrial and ventricular preparations.
- Adenosine-guanosine interactions in the isolated dog atrium.
- Anti-Nicotinic and Anti-Muscarinic Actions of Eperisone in the Isolated Canine Atrium.
- Chronotropic and inotropic effects of a new angiotensin converting enzyme inhibitor, MC-838(altiopril calcium), on the dog heart.
- Cardiovascular effects of dibutyryl cyclic AMP in the intact dog heart and the isolated cross-perfused right atrium.
- Cardiovascular effects of a new phenoxyalkylamine derivative, 2-isopropyl-5-(3-(2-methoxyphenoxy)propylamino)-2-(3,4,5-trimethoxyphenyl)valeronitrile fumarate (HV-525), in cross-circulated dog atrial preparations.
- Suppression of strychnine on the chronotropic and inotropic effects in the isolated, blood-perfused canine atrium.
- Positive inotropic and negative chronotropic effects of OPC-8490, a newly developed cardiotonic, in isolated, blood-perfused canine heart preparations.
- Differential intracardiac sympathetic and parasympathetic innervation to the SA and AV nodes in anesthetized dog hearts.
- Chronotropic, dromotropic and inotropic effects of dilazep in the intact dog heart and isolated atrial preparation.
- Cardiovascular responses to a newly developed cardiotonic agent, ZSY-39 (4-methyl-5-(4-pyridinyl)-thiazole-2-carboxyamide) in dog cross-circulated atrial and ventricular preparations.
- Cardiovascular effects of budralazine in the dog.
- Comparative study of cardiovascular effects of clonidine and alinidine in cross-perfused dog atrial preparations.
- Predominant negative inotropic effect of UTP on dog cardiac muscle.
- Inotropic and chronotropic activity of a new cardiotonic agent, DM 9278 (1,2,3,4,8,9,10,12-octahydro(2,1-b)pyrido(2,3-f)qunazolin-9-one), on isolated dog atrial and ventricular muscles.
- Ouabain-induced negative frequency-force relationship in the isolated, blood-perfused dog atrium.
- Negative chronotropic and positive inotropic effects of a unique cardioactive agent, N,N'-dicyclopropyl methyl piperazine(bis) hydrochloride(INO 2628), in isolated, blood-perfused dog atria.
- Cardiovascular effects of ZSY-27 (5-methyl-6-(4-pyridinyl)-2H-1,4-thiazine-3(4H)-onehydrochloride) in the dog cross-circulated atrial preparation.
- Different effectiveness of glucagon on the pacemaker activity and contractility in intact dog hearts and in isolated perfused right atria.
- Bradycardic effects of AQ-A 39(falipamil) in situ and in isolated, blood-perfused dog hearts comparison with alinidine and verapamil.:Comparison with Alinidine and Verapamil
- Cardiac effects of piretanide and furosemide on intact anesthetized dogs and on isolated atria.
- Pinacidil Attenuates Positive Inotropic but Not Chronotropic Responses to Norepinephrine in Isolated Dog Atrial and Venbtricular Preparations.
- Effects of Glibenclamide on Negative Cardiac Responses to Cholinerg and Purinergic Stimuli and Cromakalim in the Isolated Dog Heart.
- Hot Topics in Phospholipase A_2 Field(Diversity of Phospholipase A_2 Enzymes)
- Induction of PYPAF1 during In Vitro Maturation of Mouse Mast Cells