Cardiovascular effects of budralazine in the dog.
スポンサーリンク
概要
- 論文の詳細を見る
Cardiovascular effects of budralazine were investigated in isolated and cross-circulated dog atrial preparations. When budralazine was injected into the jugular vein of the donor dog, a hypotension was produced with slight tachycardia in a dose-related manner. At the same time, slight positive chronotropic and biphasic inotropic effects were induced in. the isolated atrium perfused with donor's arterial blood. When budralazine was injected into the cannulated sinus node artery of the isolated atrial preparation, it produced only slight negative chronotropic and inotropic responses, occasionally followed by positive responses. Vehicle injections induced monophasic negative chronotropic and inotropic effects. It is concluded that budralazine has a potent vasodilator action, a reflex-induced sympathomimetic action, but no direct cardiac stimulating properties Moreover, a direct catecholamine releasing action of budralazine does not appear to be prominent.
- International Heart Journal刊行会の論文
著者
-
Furukawa Yasuyuki
Department Of Pharmacology Shinshu University School Of Medicine
-
Chiba Shigetoshi
Departmen T Of Pharmacology Shinshu University School Of Medicine
-
Chiba Shigetoshi
Department of Pharmacology, Shinshu University School of Medicine
-
SAEGUSA Kimiaki
Department of Pharmacology and Research Laboratory for Cardiovascular Diseases, Shinshu University School of Medicine
-
OGIWARA Yasuhiro
Department of Pharmacology, Shinshu University School of Medicine
関連論文
- Periarterial Electrical Nerve Stimulation-Induced Adrenergic Vasoconstriction Inhibited by Adrenergic α_-Receptor Blockade but Not by α_-Blockade
- Different Sensitivities to α_1 Adrenoceptor Blockade on Periarterial Sympathetic Nerve-Induced Constriction by Low and High Frequencies in Canine Isolated Splenic Arteries
- Effects of Imipramine, an Uptake Inhibitor, on Double-Peaked Constrictor Responses to Periarterial Nerve Stimulation in Isolated, Per fused Canine Splenic Arteries
- Effects of Prolonged Cold Storage on Purinergic and Adrenergic Components of Sympathetic Co-transmission in Isolated Canine Splenic Arteries
- Neuroeffector Mechanisms Involved in the Regulation of Dog Splenic Arterial Tone
- Perivascular Purinergic Nerve-Induced Vasoconstrictions in Canine Isolated Splenic Arteries
- Effects of Neuropeptide Y on Double-Peaked Constrictor Responses to Periarterial Nerve Stimulation in Isolated, Perfused Canine Splenic Arteries
- Gene Expression of MASH-1, MATH-1, neuroD and NSCL-2, Basic Helix-Loop-Helix Proteins, during Neural Differentiation in P19 Embryonal Carcinoma Cells
- Botulinum Neurotoxin A Blocks Cholinergic Ganglionic Neurotransmission in the Dog Heart
- A Na^+/Ca^ Exchanger Inhibitor, KB-R7943, Caused Negative Inotropic Responses and Negative Followed by Positive Chronotropic Responses in Isolated, Blood-Perfused Dog Heart Preparations
- Propofol decreases contractility of isolated blood-perfused left ventricular muscle in the dog
- Cardiac effects of propofol and its interaction with autonomic nervous system in isolated, cross-circulated canine atria
- Effects of Low Temperature on the Chronotropic and Inotropic Responses to Zatebradine, E-4031 and Verapamil in Isolated Per fused Dog Atria
- Different Chronotropic and Inotropic Effects of EMD 57033 and EMD 53998, Ca^ Sensitizers, on Isolated, Blood-Perfused Dog Heart Preparations
- Inhibition of Delayed Rectifier K^+ Current by Dofetilide and E-4031 Differentially Affects Electrical Cardiac Responses to Vagus Stimulation in Anesthetized Dogs
- Negative Chronotropic and Inotropic Effects of U-92032, a Novel T-Type Ca^ Channel Blocker, on the Isolated, Blood-Perfused Dog Atrium
- Differences in α_1-Adrenoceptor Subtype-Mediated Vasoconstriction by Tyramine and Nerve Stimulation in Canine Splenic Artery
- Dissociation of Potentiation of Leu^ Pro^ Neuropeptide Y on Adrenergic and Purinergic Transmission in Isolated Canine Splenic Artery
- Effects of Magnesium on the Isolated, Blood-Perfused Atrial and Ventricular Preparations of the Dog Heart
- MECHANISM OF POSITIVE CHRONOTROPIC AND INOTROPIC EFFECTS INDUCED BY 4-METHYLHISTAMINE
- Chronotropic and Inotropic Effects of Bradykinin on Isolated, Blood-perfused Canine Atrium
- Effects of Temperature on Inotropic Responses of Isolated Canine Atria under Spontaneous or Electrically Paced Rhythm
- A Pharmacologic Analysis of Chronotropic and Inotropic Responses to Direct Electrical Stimulation of the Isolated, Blood-perfused. Canine Atrium
- Cardiac Arrest and Reactivation by Changes of Temperature in the Isolated, Blood-perfused Canine Heart
- Absence of Acute Cardiac Effect of Triiodothyronine in Isolated, Blood-perfused Canine Atrium
- EFFECT OF NIFEDIPINE ON FREQUENCY-FORCE RELATIONSHIP IN ISOLATED DOG LEFT VENTRICULAR MUSCLE
- POTENTIATION OF TYRAMINE ACTION BY 5-HYDROXYTRYPTAMINE IN THE DOG HEART
- Effects of Cardioactive Substances on the Post-stimulation Potentiation of Contractility in the Isolated Dog Atrium
- Effects of Optical Isomers of Verapamil on SA Nodal Pacemaker Activity and Contractility of the Isolated Dog Heart
- Direct Positive Chronotropic and Inotropic Effects of Ouabain in the Isolated and Blood-Perfused Canine Atrium
- CHRONOTROPIC RESPONSES TO LARGE DOSES OF ADENOSINE AND ATP IN DOG ISOLATED ATRIA
- DOUBLE-PEAKED POSITIVE CHRONOTROPIC RESPONSES OF ISOLATED AND CROSS-PERFUSED DOG ATRIA TO ATP
- Direct Effects of Digoxin and Deslanoside on Sinoatrial Conduction in Isolated, Blood-perfused Dog Atria
- Acute Desensitization of Adenosine by Adenosine Infusion in Isolated Dog Atria
- Dominant Anti-vagal Effect of Pentobarbital on Cardiac Responses to Intracardiac Autonomic Nerve Stimulation in the Dog
- Cardiovascular Effects of Aminophylline and Pentoxifylline on Intact Dogs and Isolated Dog Atria
- EFFECTS OF IMIPRAMINE ON FREQUENCY-FORCE RELATIONSHIP IN ISOLATED RIGHT ATRIAL MUSCLE OF THE DOG
- EFFECTS OF NICARDIPINE ON THE CROSS-PERFUSED CANINE ATRIUM
- Cardiovascular Effects of Imipramine in Intact Dogs and Isolated Dog Atria
- Analysis of Cardiac Actions of Nitroprusside in Intact Dogs and in Isolated Atria
- Chronotropic and Inotropic Effects of Captopril on the Dog Heart
- CARDIAC STIMULATING EFFECTS OF MACROCYCLIC POLYAMINES
- EFFECT OF ADENOSINE ON THE FREQUENCY-FORCE RELATIONSHIP IN THE ISOLATED DOG ATRIUM
- COMPARISON OF THE EFFECTS OF NOREPINEPHRINE AND ACETYLCHOLINE BETWEEN INTRAARTERIAL AND EXTRAVASCULAR ADMINISTRATION TO THE ISOLATED, BLOOD-PERFUSED CANINE ATRIUM
- Differences in Chronotropic and Inotropic Responses of Canine Atrial Muscle and SA Node Pacemaker Activity to Adenosine and ACh
- EFFECTS OF CYCLIC GMP ON THE SECRETION OF PANCREATIC JUICE IN THE BLOOD-PERFUSED CANINE PANCREAS
- Existence of Functional α_- and α_- but No α_-Adrenoceptor Subtypes in Rat Common Carotid Arteries
- Effects of Temperature on Norepinephrine-Induced Sinus Acceleration and Overdrive Suppression in the Isolated Dog Atrium
- Pharmacologic Analysis of Stretch-Induced Sinus Acceleration of the Isolated Dog Atrium
- EFFECTS OF METHYLISOBUTYLXANTHINE (MIX) ON THE SECRETION OF PANCREATIC JUICE IN THE BLOOD-PERFUSED CANINE PANCREAS
- POTENTIATING EFFECTS OF DIPYRIDAMOLE ON THE SECRETION OF PANCREATIC JUICE INDUCED BY SECRETIN IN THE BLOOD-PERFUSED DOG PANCREAS
- DIFFERENT INOTROPIC RESPONSES TO ADENOSINE ON THE ATRIAL AND VENTRICULAR MUSCLE OF THE DOG HEART
- DIFFERENTIAL INOTROPIC-CH RONOTROPIC ACTION OF CARTEOLOL
- Effects of L-765,314, a Selective and Potent α_-Adrenoceptor Antagonist, on Periarterial Nerve Electrical Stimulation-Induced Double-Peaked Constrictor Responses in Isolated Dog Splenic Arteries
- CARDIOVASCULAR EFFECTS OF DOBUTAMINE, DOPAMINE AND ISOPROTERENOL ON THE WHOLE ANIMAL AND ISOLATED CROSS-PERFUSED ATRIUM IN DOGS
- EFFECT OF PROSTAGLANDINS E1 AND F2α ON HEART RATE BY DIRECT INJECTION INTO THE CANINE SINUS NODE ARTERY
- The Preferential Inhibitory Effect of Olmesartan, a New Angiotensin II Type 1 Antagonist, on Sympathetic Nerve Terminals in Isolated Canine Splenic Artery
- Enhancement of Vasoconstrictor Responses to 5-HT but no to Methoxamine by Cooling in Isolated Dog Lingual and Mesenteric Arteries
- COMPARATIVE STUDY OF THE SECRETORY RESPONSE TO DOPAMINE AND SEVEN AMINO ACID CONJUGATED DERIVATIVES ON THE BLOOD-PERFUSED CANINE PANCREAS
- EFFECT OF ACETAZOLAMIDE ON THE SECRETION OF PANCREATIC JUICE INDUCED BY DOPAMINE IN DOGS
- Effect of Apomorphine on the Canine SA Node
- Effects of Salmon Calcitonin on SA Nodal Pacemaker Activity and Contractility in Isolated, Blood-Perfused Atrial and Papillary Muscle Preparations of Dogs
- Effects of Potassium Chloride on Isolated, Blood-Perfused Canine Atrial or Ventricular Muscle Preparations
- Cardiac effects of YM-09538, a new .ALPHA.- and .BETA.-adrenoceptor blocking agent, on SA nodal pacemaker activity and contractility in isolated atria and intact dogs.
- Chronotropic and inotropic effects of 3 kinds of alpha-adrenergic blockers on the isolated dog atria.
- Absence of blocking effect of burimamide and metiamide on positive chronotropic and inotropic responses to histamine in isolated dog atrium.
- Coronary Sinus Rhythm Induced by Selective Use of Catecholamine in the in Situ Dog Heart
- Negative Chronotropic Response to Norepinephrine
- SUSTAINED ATRIAL FIBRILLATION INDUCED BY CARBACHOL, METHACHOLINE AND BETHANECHOL
- DIFFERENCES IN CHRONOTROPIC AND DROMOTROPIC RESPONSES OF THE SA AND AV NODES TO ADENOSINE AND ACETYLCHOLINE
- Effect of verapamil on frequency-force relationship in isolated dog left ventricular muscle.
- Sympathetic Nerve Stimulation Activates Both .BETA.1- and .BETA.2- Adrenoceptors of SA and AV Nodes in Anesthetized Dog Hearts.
- A Negative Inotropic Effect of Omega-Conotoxin GVIA in Isolated, Blood-Perfused Dog Right Atria.
- Pharmacological analysis of positive chrono- and inotropic responses to denopamine (TA-064) in dog cross-circulated atrial and ventricular preparations.
- Cardiovascular effects of 2-amino-N-(2,6-dimethylphenyl)-N-(3-(3-pyridyl)propyl)propionamide dihydrochloride(Ro 22-9194) in the isolated, cross-perfused atrium of the dog.
- Cardiovascular responses to a newly developed phosphodiesterase inhibitor, DN-9693 (7-pyperidinyl-1,2,3,5-tetrahydroimidazo (2,1-b)-quinazolin-2-oneHCl) in dog cross-circulated atrial and ventricular preparations.
- Direct chronotropic and inotropic effects of mildronate using cross-circulated dog atrial and ventricular preparations.
- Cardiovascular effects of methylflavonolamine hydrochloride(SIPI-549) in cross-circulated canine atrial and ventricular preparations.
- Adenosine-guanosine interactions in the isolated dog atrium.
- Anti-Nicotinic and Anti-Muscarinic Actions of Eperisone in the Isolated Canine Atrium.
- Chronotropic and inotropic effects of a new angiotensin converting enzyme inhibitor, MC-838(altiopril calcium), on the dog heart.
- Cardiovascular effects of dibutyryl cyclic AMP in the intact dog heart and the isolated cross-perfused right atrium.
- Cardiovascular effects of a new phenoxyalkylamine derivative, 2-isopropyl-5-(3-(2-methoxyphenoxy)propylamino)-2-(3,4,5-trimethoxyphenyl)valeronitrile fumarate (HV-525), in cross-circulated dog atrial preparations.
- Suppression of strychnine on the chronotropic and inotropic effects in the isolated, blood-perfused canine atrium.
- Positive inotropic and negative chronotropic effects of OPC-8490, a newly developed cardiotonic, in isolated, blood-perfused canine heart preparations.
- Differential intracardiac sympathetic and parasympathetic innervation to the SA and AV nodes in anesthetized dog hearts.
- Chronotropic, dromotropic and inotropic effects of dilazep in the intact dog heart and isolated atrial preparation.
- Cardiovascular responses to a newly developed cardiotonic agent, ZSY-39 (4-methyl-5-(4-pyridinyl)-thiazole-2-carboxyamide) in dog cross-circulated atrial and ventricular preparations.
- Cardiovascular effects of budralazine in the dog.
- Comparative study of cardiovascular effects of clonidine and alinidine in cross-perfused dog atrial preparations.
- Predominant negative inotropic effect of UTP on dog cardiac muscle.
- Inotropic and chronotropic activity of a new cardiotonic agent, DM 9278 (1,2,3,4,8,9,10,12-octahydro(2,1-b)pyrido(2,3-f)qunazolin-9-one), on isolated dog atrial and ventricular muscles.
- Ouabain-induced negative frequency-force relationship in the isolated, blood-perfused dog atrium.
- Negative chronotropic and positive inotropic effects of a unique cardioactive agent, N,N'-dicyclopropyl methyl piperazine(bis) hydrochloride(INO 2628), in isolated, blood-perfused dog atria.
- Cardiovascular effects of ZSY-27 (5-methyl-6-(4-pyridinyl)-2H-1,4-thiazine-3(4H)-onehydrochloride) in the dog cross-circulated atrial preparation.
- Different effectiveness of glucagon on the pacemaker activity and contractility in intact dog hearts and in isolated perfused right atria.
- Bradycardic effects of AQ-A 39(falipamil) in situ and in isolated, blood-perfused dog hearts comparison with alinidine and verapamil.:Comparison with Alinidine and Verapamil
- Cardiac effects of piretanide and furosemide on intact anesthetized dogs and on isolated atria.
- Pinacidil Attenuates Positive Inotropic but Not Chronotropic Responses to Norepinephrine in Isolated Dog Atrial and Venbtricular Preparations.
- Effects of Glibenclamide on Negative Cardiac Responses to Cholinerg and Purinergic Stimuli and Cromakalim in the Isolated Dog Heart.