DOUBLE-PEAKED POSITIVE CHRONOTROPIC RESPONSES OF ISOLATED AND CROSS-PERFUSED DOG ATRIA TO ATP
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概要
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The effects of a large amount of adenosine and ATP (100 to 3000 μg) were investigated on sinus rate and developed tension, using the isolated dog atrium which was perfused with arterial blood from a heparinized donor dog. Each of the substances used for study was administered into the cannulated sinus node artery of the isolated atrium. Adenosine caused monophasic negative chronotropic and inotropic effects in a doserelated manner. However, ATP induced two-peaked positive chronotropic phases during a long-lasting negative chronotropic phase, i.e., initially, brief positive (t-1) effects and secondarily, relatively longer positive chronotropic (t-2) effects. These responses were repetitively induced during the experiment. The t-1 and t-2 were not influenced by treatment with propranolol which significantly blocked the positive chronotropic effect of norepinephrine. Aminophylline treatment significantly suppressed t-2 but not t-1. Quinidine (100-1000 μg) did not affect either the t-1 or t-2. It is suggested that ATP-induced tachycardia in the dog is partially due to activation of the P<SUB>1</SUB>-purinoceptors named by Burnstock.
- 社団法人 日本薬理学会の論文
著者
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Chiba Shigetoshi
Department Of Molecular Pharmacology Shinshu University School Of Medicine
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Shimotori Masahiro
Department Of Material Science Graduate School Of Science Osaka City University
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KOBAYASHI Miyoharu
Department of Pharmacology, Faculty of Medicine, Shinshu University
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Kobayashi Miyoharu
Department Of Pharmacology Faculty Of Medicine Shinshu University
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Chiba Shigetoshi
Departmen T Of Pharmacology Shinshu University School Of Medicine
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SHIMOTORI Masahiro
Department of Pharmacology, School of Medicine, Shishu University
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KOBAYASHI Miyoharu
Department of Pharmacology, School of Medicine, Shishu University
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KOBAYASHI Miyoharu
Department of Pharmacology and Research Laboratory for Cardiovascular Diseases Shinshu University School of Medicine
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CHIBA Shigetoshi
Department of Pharmacology, School of Medicine, Shishu University
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