Differences between negative chrono-, dromo- and inotropic actions of cholinomimetics in the dog isolated atrium.
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概要
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Both bethanechol and physostigmine produced dose-dependent negative chrono-, dromo- and inotropic effects in the dog isolated atrial preparation. Within a relatively small dose of bethanechol and physostigmine, negative inotropic effect was clearly induced but no significant chrono- and dromotropic changes were observed. With a relatively large dose, the two cholinomimetics caused negative chrono-, dromo- and inotropic effects. The order of the negative actions of the drugs in % changes was inotropism >dromotropism≥chronotropism. These results indicate that pacemaker activity, sinoatrial conductivity and atrial contractility may be differentially sensitive to actions of cholinomimetics.
- International Heart Journal刊行会の論文
著者
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Shimotori Masahiro
Department Of Material Science Graduate School Of Science Osaka City University
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Chiba Shigetoshi
Departmen T Of Pharmacology Shinshu University School Of Medicine
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KOBAYASHI Miyoharu
Department of Pharmacology and Research Laboratory for Cardiovascular Diseases Shinshu University School of Medicine
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