Direct effects of catecholamines and tyramine on sinoatrial conduction in isolated and blood-perfused dog atria.
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概要
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We have investigated the effects of catecholamines (dopamine, norepinephrine, epinephrine and isoproterenol) and tyramine on sinoatrial conduction time (SACT), sinus cycle length (SCL) and developed tension (DT) in isolated atrial muscle, using an isolated and blood-perfused dog atrial preparation, perfused with heparinized blood from the carotid artery of the anesthetized donor dog. Each substance was continuously administered intraarterially into the cannulated sinus node artery. They had dose-dependent positive chronotropic and inotropic effects. Each produced not only a shortening but a prolongation of SACT. In experiments in which only a shortening occurred, the order of the potency for inducing the shortening of the SACT was isoproterenol>norepinephrine=epinephrine>dopamine>tyramine. The ratio of doses required to produce roughly a 15-25% shortening of the SACT was 1: 10: 10: 100: 300, respectively. The isoproterenol-induced shortening of the SACT was inhibited by treatment with propranolol. Tyramine-induced shortening was inhibited by imipramine. From these results, it is suggested that sympathomimetic amines induce a short-ening of SACT through adrenergic beta-receptors and also readily induce a pacemaker shift in the SA nodal area.
- International Heart Journal刊行会の論文
著者
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Shimotori Masahiro
Department Of Material Science Graduate School Of Science Osaka City University
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Chiba Shigetoshi
Departmen T Of Pharmacology Shinshu University School Of Medicine
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Chiba Shigetoshi
Department of Pharmacology, Shinshu University School of Medicine
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KOBAYASHI Miyoharu
Department of Pharmacology and Research Laboratory for Cardiovascular Diseases Shinshu University School of Medicine
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SHIMOTORI Masahiro
Department of Pharmacology, Shinshu University School of Medicine
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KOBAYASHI Miyoharu
Department of Pharmacology, Shinshu University School of Medicine
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