Absence of Acute Cardiac Effect of Triiodothyronine in Isolated, Blood-perfused Canine Atrium
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概要
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Effects of triiodothyronine (T3) on SA node pacemaker activity, atrial contractility and on chronotropic and inotropic responses to norepinephrine were investigated, using 9 isolated, blood-perfused dog atrium preparations. T3 (0.001pg-0.1μg) did not cause a significant direct action injected into the cannulated sinus node artery. When T3 (10pg/min, 40pg/min, 0.1μg/min, or 0.4μg/min) was continuously infused into the sinus node artery, both positive chronotropic and inotropic actions of norepinephrine (0.03μg-0.3μg) were not influenced.From these results, it is concluded that T3 has neither acutely direct chronotropic nor inotropic effects, and also T3 does not have an acute effect on responses to norepinephrine in the isolated, blood-perfused canine atrium.
- International Heart Journal刊行会の論文
著者
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Chiba Shigetoshi
Department Of Molecular Pharmacology Shinshu University School Of Medicine
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Furukawa Yasuyuki
Department Of Pharmacology Shinshu University School Of Medicine
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KOBAYASHI Miyoharu
Department of Pharmacology, Faculty of Medicine, Shinshu University
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Kobayashi Miyoharu
Department Of Pharmacology Faculty Of Medicine Shinshu University
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Chiba Shigetoshi
Departmen T Of Pharmacology Shinshu University School Of Medicine
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KOBAYASHI Miyoharu
Department of Pharmacology and Research Laboratory for Cardiovascular Diseases Shinshu University School of Medicine
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