Effect of Hypothermic Anoxic Arrest on Myocardial Contractility in the Isolated Blood-Perfused Canine Left Ventricular Muscle
スポンサーリンク
概要
- 論文の詳細を見る
The present studies were performed to evaluate the protective effect of topical hypothermia on anoxic heart. The myocardial protection was assessed by myocardial contractility in the isolated blood-perfused electrically driven canine left ventricular muscle. The isometric tension and the rate of rise of tension development (dT/dt) were measured before and after hypothermic anoxic arrest and percent recovery of these values was used as a parameter of myocardial contractility. The percent recovery rates of 100, 95, 90, and 65 were obtained after acute anoxia of 90, 120, 150, and 180min, respectively at the myocardial temperature of 17°C. These data suggest that the safe limit of acute anoxia at the myocardial temperature of 17°C is defined as 90min in this experimental model and it can be extended to 120min at the myocardial temperature below 17°C.
- International Heart Journal刊行会の論文
著者
-
SHIDA Hiroshi
Second Department of Surgery, Shinshu University School of Medicine
-
Kobayashi Miyoharu
Department Of Pharmacology Faculty Of Medicine Shinshu University
-
SHIDA Hiroshi
Second Department of Surgery, Faculty of Medicine, Shinshu University
-
KOBAYASHI Miyoharu
Department of Pharmacology and Research Laboratory for Cardiovascular Diseases Shinshu University School of Medicine
関連論文
- EXPERIMENTAL STUDIES ON MYOCARDIAL METABOLISM OF CARBOHYDRATE AND LIPID IN SURFACE-INDUCED DEEP HYPOTHERMIA
- Angiotensin II-Induced Myocardial Damage with a Special Reference to Low Cardiac Output Syndrome
- MECHANISM OF POSITIVE CHRONOTROPIC AND INOTROPIC EFFECTS INDUCED BY 4-METHYLHISTAMINE
- Chronotropic and Inotropic Effects of Bradykinin on Isolated, Blood-perfused Canine Atrium
- Effects of Temperature on Inotropic Responses of Isolated Canine Atria under Spontaneous or Electrically Paced Rhythm
- A Pharmacologic Analysis of Chronotropic and Inotropic Responses to Direct Electrical Stimulation of the Isolated, Blood-perfused. Canine Atrium
- Cardiac Arrest and Reactivation by Changes of Temperature in the Isolated, Blood-perfused Canine Heart
- Absence of Acute Cardiac Effect of Triiodothyronine in Isolated, Blood-perfused Canine Atrium
- EFFECT OF NIFEDIPINE ON FREQUENCY-FORCE RELATIONSHIP IN ISOLATED DOG LEFT VENTRICULAR MUSCLE
- POTENTIATION OF TYRAMINE ACTION BY 5-HYDROXYTRYPTAMINE IN THE DOG HEART
- Effects of Cardioactive Substances on the Post-stimulation Potentiation of Contractility in the Isolated Dog Atrium
- Effects of Optical Isomers of Verapamil on SA Nodal Pacemaker Activity and Contractility of the Isolated Dog Heart
- Direct Positive Chronotropic and Inotropic Effects of Ouabain in the Isolated and Blood-Perfused Canine Atrium
- CHRONOTROPIC RESPONSES TO LARGE DOSES OF ADENOSINE AND ATP IN DOG ISOLATED ATRIA
- DOUBLE-PEAKED POSITIVE CHRONOTROPIC RESPONSES OF ISOLATED AND CROSS-PERFUSED DOG ATRIA TO ATP
- Direct Effects of Digoxin and Deslanoside on Sinoatrial Conduction in Isolated, Blood-perfused Dog Atria
- Chronotropic and Inotropic Effects of Captopril on the Dog Heart
- Effect of Dilazep on Myocardial Contractility Following Acute Ischemia and Reperfusion in Isolated Blood-Perfused Canine Left Ventricular Muscle
- Effect of Hypothermic Anoxic Arrest on Myocardial Contractility in the Isolated Blood-Perfused Canine Left Ventricular Muscle
- EFFECT OF HYPOTHERMIA DURING ISCHEMIA ON MYOCARDIAL CONTRACTILITY IN NONHYPERTROPHIED AND HYPERTROPHIED VENTRICLES
- CARDIOVASCULAR EFFECTS OF DOBUTAMINE, DOPAMINE AND ISOPROTERENOL ON THE WHOLE ANIMAL AND ISOLATED CROSS-PERFUSED ATRIUM IN DOGS
- Adenosine-guanosine interactions in the isolated dog atrium.
- Cardiovascular effects of digitalis on intact dogs and isolated cross-perfused atria.
- Direct effects of catecholamines and tyramine on sinoatrial conduction in isolated and blood-perfused dog atria.
- A comparative study of sinoatrial conduction time with therapeutic doses of antiarrhythmic agents in isolated cross-perfused canine atria.
- Differences between negative chrono-, dromo- and inotropic actions of cholinomimetics in the dog isolated atrium.
- Chronotropic, dromotropic and inotropic effects of dilazep in the intact dog heart and isolated atrial preparation.
- Predominant negative inotropic effect of UTP on dog cardiac muscle.
- Effects of dopamine on sinoatrial conduction in isolated, blood-perfused dog atria.