EFFECT OF HYPOTHERMIA DURING ISCHEMIA ON MYOCARDIAL CONTRACTILITY IN NONHYPERTROPHIED AND HYPERTROPHIED VENTRICLES
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概要
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The effect of hypothermic ischemic arrest on myocardial contractility was investigated with use of isolated blood-perfused canine heart preparation in the hypertrophied left ventricle created by supravalvular aortic stenosis and the nonhypertrophied ventricle. The following results were obtained : The percent recovery rate of net developed tension during reperfusion after an ischemic period of 150 minutes at the myocardial temperature of 17℃ was 90±9% in the nonhypertrophied muscle, while it was 70±19% in the hypertrophied muscle, that is, hypertrophied left ventricle was considered to be more vulnerable to ischemia as compared to nonhypertrophied left ventricle, suggesting the necessity of more intense myocardial protection in addition to cardiac hypothermia against ischemia in the hypertrophied heart.
- 社団法人日本循環器学会の論文
- 1980-04-20
著者
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Shida Hiroshi
The Second Department Of Surgery Faculty Of Medicine Shinshu University
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Kobayashi Miyoharu
Department Of Pharmacology Faculty Of Medicine Shinshu University
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KOBAYASHI Miyoharu
Department of Pharmacology and Research Laboratory for Cardiovascular Diseases Shinshu University School of Medicine
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