Effects of Cardioactive Substances on the Post-stimulation Potentiation of Contractility in the Isolated Dog Atrium
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概要
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Effects of cardioactive substances on the post-stimulation potentiation of atrial contractility were studied in 17 isolated, blood-perfused preparations of dogs. Maximum degree of the post-stimulation potentiation was obtained over approximately 3.5Hz within 5-60 sec of stimulation. Each drug was administered directly into the cannulated sinus node artery of isolated atrium. An adequate dose of verapamil, manganese chloride, or pentobarbital which caused marked depression of contractility did not significantly suppress the post-stimulation potentiation in percent changes. The post-stimulation potentiation was not inhibited by continuous infusion of adenosine, which caused a negative inotropic effect. Tetrodotoxin, propranolol, or caffeine also never suppressed the post-stimulation potentiation but ouabain abolished it in the majority of cases.
- International Heart Journal刊行会の論文
著者
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Chiba Shigetoshi
Department Of Molecular Pharmacology Shinshu University School Of Medicine
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Furukawa Yasuyuki
Department Of Pharmacology Shinshu University School Of Medicine
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KOBAYASHI Miyoharu
Department of Pharmacology, Faculty of Medicine, Shinshu University
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Kobayashi Miyoharu
Department Of Pharmacology Faculty Of Medicine Shinshu University
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Chiba Shigetoshi
Departmen T Of Pharmacology Shinshu University School Of Medicine
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CHIBA Shigetoshi
Department of Pharmacology, Faculty of Medicine, Shinshu University
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KOBAYASHI Miyoharu
Department of Pharmacology and Research Laboratory for Cardiovascular Diseases Shinshu University School of Medicine
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