Suppression of strychnine on the chronotropic and inotropic effects in the isolated, blood-perfused canine atrium.
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概要
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In the isolated, blood-perfused dog atrium, strychnine evoked dose-dependent decreases in atrial rate and contractile force, and the negative cardiac effects were not influenced by atropine. Strychnine suppressed dose-dependently the negative chronotropic and inotropic responses to intramural parasympathetic nerve stimulation, but not the response to acetylcholine. These results suggest that strychnine has direct cardiac depressant properties and inhibits the release of acetylcholine from parasympathetic nerve terminals in isolated dog atrium.
- 公益社団法人 日本薬理学会の論文
著者
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Furukawa Yasuyuki
Department Of Pharmacology Shinshu University School Of Medicine
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Chiba Shigetoshi
Departmen T Of Pharmacology Shinshu University School Of Medicine
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SAEGUSA Kimiaki
Department of Pharmacology and Research Laboratory for Cardiovascular Diseases, Shinshu University School of Medicine
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