COMPARATIVE STUDY OF THE SECRETORY RESPONSE TO DOPAMINE AND SEVEN AMINO ACID CONJUGATED DERIVATIVES ON THE BLOOD-PERFUSED CANINE PANCREAS
スポンサーリンク
概要
- 論文の詳細を見る
The secretory responses to seven dopamine amino acid conjugated derivatives were compared with those to dopamine, using blood-perfused canine pancreas preparations. Each of these dopamine derivatives produced a dose dependent increase in the secretion of pancreatic juice. The rank order of the secretory responses and relative potency (dopamine =1) was: N-Ileu-dopamine (0.4)>N-Ala-Glu-dopamine (0.2)>N-γ-Glu-dopamine (0.1) = N-Gly-Pro-dopamine (0.1)>N-Gly-Gly-dopamine (0.01)>N-Gly-Gly-Leu-dopamine (0.005)=N-Gly-Gly-Pro-dopamine (0.005). The duration of action of doses of the derivatives which produced approximately equal secretory responses was about 1.2-2.7 times longer than that of dopamine. Dopamine and N-Ileu-dopamine which has the most potent secretagogue property among seven dopamine derivatives produced a secretin-like secretion of the pancreatic juice containing a high concentration of bicarbonate but had little effect on protein output with lower amylase activity.
- 社団法人 日本薬理学会の論文
著者
-
IWATSUKI Kazuhiko
Department of Pharmacology, Shinshu University School of Medicine
-
Chiba Shigetoshi
Departmen T Of Pharmacology Shinshu University School Of Medicine
-
Iwatsuki Kazuhiko
Department Of Pharmacology Shinshu University School Of Medicine
-
CHIBA Shigetoshi
Department of Pharmacology, Faculty of Medicine, Shinshu University
-
IWATSUKI Kazuhiko
Department of Pharmacology, Faculty of Medicine, Shinshu University
関連論文
- D-1 Dopamine Receptors Mediate Dopamine-Induced Pancreatic Exocrine Secretion in Anesthetized Dogs
- Periarterial Electrical Nerve Stimulation-Induced Adrenergic Vasoconstriction Inhibited by Adrenergic α_-Receptor Blockade but Not by α_-Blockade
- Different Sensitivities to α_1 Adrenoceptor Blockade on Periarterial Sympathetic Nerve-Induced Constriction by Low and High Frequencies in Canine Isolated Splenic Arteries
- Effects of Imipramine, an Uptake Inhibitor, on Double-Peaked Constrictor Responses to Periarterial Nerve Stimulation in Isolated, Per fused Canine Splenic Arteries
- Effects of Prolonged Cold Storage on Purinergic and Adrenergic Components of Sympathetic Co-transmission in Isolated Canine Splenic Arteries
- Neuroeffector Mechanisms Involved in the Regulation of Dog Splenic Arterial Tone
- Perivascular Purinergic Nerve-Induced Vasoconstrictions in Canine Isolated Splenic Arteries
- Effects of Neuropeptide Y on Double-Peaked Constrictor Responses to Periarterial Nerve Stimulation in Isolated, Perfused Canine Splenic Arteries
- Gene Expression of MASH-1, MATH-1, neuroD and NSCL-2, Basic Helix-Loop-Helix Proteins, during Neural Differentiation in P19 Embryonal Carcinoma Cells
- Botulinum Neurotoxin A Blocks Cholinergic Ganglionic Neurotransmission in the Dog Heart
- A Na^+/Ca^ Exchanger Inhibitor, KB-R7943, Caused Negative Inotropic Responses and Negative Followed by Positive Chronotropic Responses in Isolated, Blood-Perfused Dog Heart Preparations
- Propofol decreases contractility of isolated blood-perfused left ventricular muscle in the dog
- Cardiac effects of propofol and its interaction with autonomic nervous system in isolated, cross-circulated canine atria
- Effects of Low Temperature on the Chronotropic and Inotropic Responses to Zatebradine, E-4031 and Verapamil in Isolated Per fused Dog Atria
- Different Chronotropic and Inotropic Effects of EMD 57033 and EMD 53998, Ca^ Sensitizers, on Isolated, Blood-Perfused Dog Heart Preparations
- Inhibition of Delayed Rectifier K^+ Current by Dofetilide and E-4031 Differentially Affects Electrical Cardiac Responses to Vagus Stimulation in Anesthetized Dogs
- Negative Chronotropic and Inotropic Effects of U-92032, a Novel T-Type Ca^ Channel Blocker, on the Isolated, Blood-Perfused Dog Atrium
- Differences in α_1-Adrenoceptor Subtype-Mediated Vasoconstriction by Tyramine and Nerve Stimulation in Canine Splenic Artery
- Dissociation of Potentiation of Leu^ Pro^ Neuropeptide Y on Adrenergic and Purinergic Transmission in Isolated Canine Splenic Artery
- Effects of Magnesium on the Isolated, Blood-Perfused Atrial and Ventricular Preparations of the Dog Heart
- MECHANISM OF POSITIVE CHRONOTROPIC AND INOTROPIC EFFECTS INDUCED BY 4-METHYLHISTAMINE
- Chronotropic and Inotropic Effects of Bradykinin on Isolated, Blood-perfused Canine Atrium
- Effects of Temperature on Inotropic Responses of Isolated Canine Atria under Spontaneous or Electrically Paced Rhythm
- A Pharmacologic Analysis of Chronotropic and Inotropic Responses to Direct Electrical Stimulation of the Isolated, Blood-perfused. Canine Atrium
- Cardiac Arrest and Reactivation by Changes of Temperature in the Isolated, Blood-perfused Canine Heart
- Absence of Acute Cardiac Effect of Triiodothyronine in Isolated, Blood-perfused Canine Atrium
- EFFECT OF NIFEDIPINE ON FREQUENCY-FORCE RELATIONSHIP IN ISOLATED DOG LEFT VENTRICULAR MUSCLE
- POTENTIATION OF TYRAMINE ACTION BY 5-HYDROXYTRYPTAMINE IN THE DOG HEART
- Effects of Cardioactive Substances on the Post-stimulation Potentiation of Contractility in the Isolated Dog Atrium
- Effects of Optical Isomers of Verapamil on SA Nodal Pacemaker Activity and Contractility of the Isolated Dog Heart
- Direct Positive Chronotropic and Inotropic Effects of Ouabain in the Isolated and Blood-Perfused Canine Atrium
- CHRONOTROPIC RESPONSES TO LARGE DOSES OF ADENOSINE AND ATP IN DOG ISOLATED ATRIA
- DOUBLE-PEAKED POSITIVE CHRONOTROPIC RESPONSES OF ISOLATED AND CROSS-PERFUSED DOG ATRIA TO ATP
- Direct Effects of Digoxin and Deslanoside on Sinoatrial Conduction in Isolated, Blood-perfused Dog Atria
- Acute Desensitization of Adenosine by Adenosine Infusion in Isolated Dog Atria
- Dominant Anti-vagal Effect of Pentobarbital on Cardiac Responses to Intracardiac Autonomic Nerve Stimulation in the Dog
- Cardiovascular Effects of Aminophylline and Pentoxifylline on Intact Dogs and Isolated Dog Atria
- EFFECTS OF IMIPRAMINE ON FREQUENCY-FORCE RELATIONSHIP IN ISOLATED RIGHT ATRIAL MUSCLE OF THE DOG
- EFFECTS OF NICARDIPINE ON THE CROSS-PERFUSED CANINE ATRIUM
- Cardiovascular Effects of Imipramine in Intact Dogs and Isolated Dog Atria
- Analysis of Cardiac Actions of Nitroprusside in Intact Dogs and in Isolated Atria
- Chronotropic and Inotropic Effects of Captopril on the Dog Heart
- CARDIAC STIMULATING EFFECTS OF MACROCYCLIC POLYAMINES
- EFFECT OF ADENOSINE ON THE FREQUENCY-FORCE RELATIONSHIP IN THE ISOLATED DOG ATRIUM
- COMPARISON OF THE EFFECTS OF NOREPINEPHRINE AND ACETYLCHOLINE BETWEEN INTRAARTERIAL AND EXTRAVASCULAR ADMINISTRATION TO THE ISOLATED, BLOOD-PERFUSED CANINE ATRIUM
- ENHANCEMENT OF DOPAMINE-INDUCED STIMULATION OF PANCREATIC SECRETION BY 5-DIMETHYLDITHIO-CARBAMYLPICOLINIC ACID (YP-279), A DOPAMINE β-HYDROXYLASE INHIBITOR
- Differences in Chronotropic and Inotropic Responses of Canine Atrial Muscle and SA Node Pacemaker Activity to Adenosine and ACh
- EFFECTS OF CYCLIC GMP ON THE SECRETION OF PANCREATIC JUICE IN THE BLOOD-PERFUSED CANINE PANCREAS
- Existence of Functional α_- and α_- but No α_-Adrenoceptor Subtypes in Rat Common Carotid Arteries
- Effects of Temperature on Norepinephrine-Induced Sinus Acceleration and Overdrive Suppression in the Isolated Dog Atrium
- Pharmacologic Analysis of Stretch-Induced Sinus Acceleration of the Isolated Dog Atrium
- EFFECTS OF METHYLISOBUTYLXANTHINE (MIX) ON THE SECRETION OF PANCREATIC JUICE IN THE BLOOD-PERFUSED CANINE PANCREAS
- POTENTIATING EFFECTS OF DIPYRIDAMOLE ON THE SECRETION OF PANCREATIC JUICE INDUCED BY SECRETIN IN THE BLOOD-PERFUSED DOG PANCREAS
- DIFFERENT INOTROPIC RESPONSES TO ADENOSINE ON THE ATRIAL AND VENTRICULAR MUSCLE OF THE DOG HEART
- DIFFERENTIAL INOTROPIC-CH RONOTROPIC ACTION OF CARTEOLOL
- Effects of L-765,314, a Selective and Potent α_-Adrenoceptor Antagonist, on Periarterial Nerve Electrical Stimulation-Induced Double-Peaked Constrictor Responses in Isolated Dog Splenic Arteries
- CARDIOVASCULAR EFFECTS OF DOBUTAMINE, DOPAMINE AND ISOPROTERENOL ON THE WHOLE ANIMAL AND ISOLATED CROSS-PERFUSED ATRIUM IN DOGS
- EFFECT OF PROSTAGLANDINS E1 AND F2α ON HEART RATE BY DIRECT INJECTION INTO THE CANINE SINUS NODE ARTERY
- The Preferential Inhibitory Effect of Olmesartan, a New Angiotensin II Type 1 Antagonist, on Sympathetic Nerve Terminals in Isolated Canine Splenic Artery
- Enhancement of Vasoconstrictor Responses to 5-HT but no to Methoxamine by Cooling in Isolated Dog Lingual and Mesenteric Arteries
- INCREASED PROLYL HYDROXYLASE ACTIVITY IN THE AORTA AND HEART IN RAT AFTER INDUCTION OF ACUTE HYPERTENSION
- COMPARATIVE STUDY OF THE SECRETORY RESPONSE TO DOPAMINE AND SEVEN AMINO ACID CONJUGATED DERIVATIVES ON THE BLOOD-PERFUSED CANINE PANCREAS
- EFFECT OF ACETAZOLAMIDE ON THE SECRETION OF PANCREATIC JUICE INDUCED BY DOPAMINE IN DOGS
- Effect of Apomorphine on the Canine SA Node
- Effects of Salmon Calcitonin on SA Nodal Pacemaker Activity and Contractility in Isolated, Blood-Perfused Atrial and Papillary Muscle Preparations of Dogs
- Effects of Potassium Chloride on Isolated, Blood-Perfused Canine Atrial or Ventricular Muscle Preparations
- Cardiac effects of YM-09538, a new .ALPHA.- and .BETA.-adrenoceptor blocking agent, on SA nodal pacemaker activity and contractility in isolated atria and intact dogs.
- Chronotropic and inotropic effects of 3 kinds of alpha-adrenergic blockers on the isolated dog atria.
- Absence of blocking effect of burimamide and metiamide on positive chronotropic and inotropic responses to histamine in isolated dog atrium.
- Coronary Sinus Rhythm Induced by Selective Use of Catecholamine in the in Situ Dog Heart
- Negative Chronotropic Response to Norepinephrine
- SUSTAINED ATRIAL FIBRILLATION INDUCED BY CARBACHOL, METHACHOLINE AND BETHANECHOL
- DIFFERENCES IN CHRONOTROPIC AND DROMOTROPIC RESPONSES OF THE SA AND AV NODES TO ADENOSINE AND ACETYLCHOLINE
- Effect of verapamil on frequency-force relationship in isolated dog left ventricular muscle.
- Sympathetic Nerve Stimulation Activates Both .BETA.1- and .BETA.2- Adrenoceptors of SA and AV Nodes in Anesthetized Dog Hearts.
- A Negative Inotropic Effect of Omega-Conotoxin GVIA in Isolated, Blood-Perfused Dog Right Atria.
- Pharmacological analysis of positive chrono- and inotropic responses to denopamine (TA-064) in dog cross-circulated atrial and ventricular preparations.
- Cardiovascular effects of 2-amino-N-(2,6-dimethylphenyl)-N-(3-(3-pyridyl)propyl)propionamide dihydrochloride(Ro 22-9194) in the isolated, cross-perfused atrium of the dog.
- Pharmacological analysis of cardiac effects of a central cholinergic agent, WEB 1881-FU, in isolated canine heart preparations.
- Cardiovascular responses to a newly developed phosphodiesterase inhibitor, DN-9693 (7-pyperidinyl-1,2,3,5-tetrahydroimidazo (2,1-b)-quinazolin-2-oneHCl) in dog cross-circulated atrial and ventricular preparations.
- Direct chronotropic and inotropic effects of mildronate using cross-circulated dog atrial and ventricular preparations.
- Cardiovascular effects of methylflavonolamine hydrochloride(SIPI-549) in cross-circulated canine atrial and ventricular preparations.
- Effects of Phentolamine on the SA Node of the Dog Heart In Situ
- BLOCKING EFFECT OF DESMETHYLIMIPRAMINE ON DOPAMINE-INDUCED SINUS ACCELERATION
- PHARMACOLOGIC ANALYSIS OF NICOTINE AND DIMETHYLPHENYLPIPERAZINIUM ON PACEMAKER ACTIVITY OF THE SA NODE IN THE DOG
- Effect of Bethanechol, Methacholine and Carbachol on AV Conduction of the Dog Heart
- Absence of Blocking Effect of Quinidine on Responses to Norepinephrine in the Isolated Dog Atrium
- Effects of Verapamil on the Blood-Perfused, Isolated Atrium Preparation of the Dog Heart
- Adenosine-guanosine interactions in the isolated dog atrium.
- Perfusion-time-dependent appearance of blocking effect of diltiazem on norepinephrine-induced vasoconstriction in isolated, perfused dog pulmonary veins.
- Anti-Nicotinic and Anti-Muscarinic Actions of Eperisone in the Isolated Canine Atrium.
- Chronotropic and inotropic effects of a new angiotensin converting enzyme inhibitor, MC-838(altiopril calcium), on the dog heart.
- Cardiovascular effects of dibutyryl cyclic AMP in the intact dog heart and the isolated cross-perfused right atrium.
- Cardiovascular effects of a new phenoxyalkylamine derivative, 2-isopropyl-5-(3-(2-methoxyphenoxy)propylamino)-2-(3,4,5-trimethoxyphenyl)valeronitrile fumarate (HV-525), in cross-circulated dog atrial preparations.
- Suppression of strychnine on the chronotropic and inotropic effects in the isolated, blood-perfused canine atrium.
- Cardiovascular effects of digitalis on intact dogs and isolated cross-perfused atria.
- Positive inotropic and negative chronotropic effects of OPC-8490, a newly developed cardiotonic, in isolated, blood-perfused canine heart preparations.
- Differential intracardiac sympathetic and parasympathetic innervation to the SA and AV nodes in anesthetized dog hearts.
- An increase of tissue cyclic AMP level by adenosine in the dog pancreas without stimulation of exocrine secretion.
- Cardiovascular effects of an ionophorous antibiotic, lonomycin A, in anesthetized dogs.